The Cerebellum

, Volume 16, Issue 4, pp 802–811 | Cite as

Gap Junction Modulation of Low-Frequency Oscillations in the Cerebellar Granule Cell Layer

  • Jennifer Claire Robinson
  • C. Andrew Chapman
  • Richard CourtemancheEmail author
Original Paper


Local field potential (LFP) oscillations in the granule cell layer (GCL) of the cerebellar cortex have been identified previously in the awake rat and monkey during immobility. These low-frequency oscillations are thought to be generated through local circuit interactions between Golgi cells and granule cells within the GCL. Golgi cells display rhythmic firing and pacemaking properties, and also are electrically coupled through gap junctions within the GCL. Here, we tested if gap junctions in the rat cerebellar cortex contribute to the generation of LFP oscillations in the GCL. We recorded LFP oscillations under urethane anesthesia, and examined the effects of local infusion of gap junction blockers on 5–15 Hz oscillations. Local infusion of the gap junction blockers carbenoxolone and mefloquine resulted in significant decreases in the power of oscillations over a 30-min period, but the power of oscillations was unchanged in control experiments following vehicle injections. In addition, infusion of gap junction blockers had no significant effect on multi-unit activity, suggesting that the attenuation of low-frequency oscillations was likely due to reductions in electrical coupling rather than a decreased excitability within the granule cell layer. Our results indicate that electrical coupling among the Golgi cell networks in the cerebellar cortex contributes to the local circuit mechanisms that promote the occurrence of GCL LFP slow oscillations in the anesthetized rat.


Electrical synapses Cerebellar cortex Brain waves Electrophysiology Oscillations 



The authors wish to thank Drs. Clément Léna, Daniela Popa, and Stéphane Dieudonné for their helpful discussions and Ariana Frederick for her help in figure preparation. We also acknowledge the technical contribution of Ricardo Ortiz-Pulido in preliminary experiments.

Compliance with Ethical Standards

Experimental procedures conformed to the guidelines of the Canadian Council on Animal Care and the Concordia University Animal Research Ethics Committee.


This work profited from grants from the NAAR/Autism Speaks (USA) and the Natural Sciences and Engineering Research Council of Canada to RC and from the Concordia VPRGS Seed Fund to RC and CAC. Both are members of the FRQS Groupe de Recherche en Neurobiologie Comportementale (CSBN).

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Jennifer Claire Robinson
    • 1
  • C. Andrew Chapman
    • 2
  • Richard Courtemanche
    • 1
    Email author
  1. 1.Department of Exercise Science, and the FRQS Groupe de Recherche en Neurobiologie Comportementale (CSBN)Concordia UniversityMontrealCanada
  2. 2.Department of Psychology, and the FRQS Groupe de Recherche en Neurobiologie Comportementale (CSBN)Concordia UniversityMontrealCanada

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