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Models of Calcium Dynamics in Cerebellar Granule Cells

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Abstract

Intracellular calcium dynamics is critical for many functions of cerebellar granule cells (GrCs) including membrane excitability, synaptic plasticity, apoptosis, and regulation of gene transcription. Recent measurements of calcium responses in GrCs to depolarization and synaptic stimulation reveal spatial compartmentalization and heterogeneity within dendrites of these cells. However, the main determinants of local calcium dynamics in GrCs are still poorly understood. One reason is that there have been few published studies of calcium dynamics in intact GrCs in their native environment. In the absence of complete information, biophysically realistic models are useful for testing whether specific Ca2+ handling mechanisms may account for existing experimental observations. Simulation results can be used to identify critical measurements that would discriminate between different models. In this review, we briefly describe experimental studies and phenomenological models of Ca2+ signaling in GrC, and then discuss a particular biophysical model, with a special emphasis on an approach for obtaining information regarding the distribution of Ca2+ handling systems under conditions of incomplete experimental data. Use of this approach suggests that Ca2+ channels and fixed endogenous Ca2+ buffers are highly heterogeneously distributed in GrCs. Research avenues for investigating calcium dynamics in GrCs by a combination of experimental and modeling studies are proposed.

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Acknowledgements

I would like to thank sincerely David Friel for helpful comments and constant support and Thomas Nielsen for help with editing.

Conflict of Interest Statement

I declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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  1. Department of General Physiology of Nervous System, A. A. Bogomoletz Institute of Physiology, 4 Bogomoletz St., Kyiv, 01024, Ukraine

    Elena È. Saftenku

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Saftenku, E.È. Models of Calcium Dynamics in Cerebellar Granule Cells. Cerebellum 11, 85–101 (2012). https://doi.org/10.1007/s12311-010-0216-3

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