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Pogo: A Novel Spontaneous Ataxic Mutant Mouse

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Abstract

The Pogo (pogo/pogo) mouse is a naturally occurring neurological mutant from a Korean wild-type mouse characterized by loss of balance and motor coordination due to dysfunction of the cerebellum. The Pogo mutation is believed to be an allele of P/Q-type calcium channel mutants such as tottering, leaner, and rolling mouse Nagoya. These mutants have been served as mouse models for a group of neurodegenerative diseases. The overall aim of this minireview is to summarize our current understanding of the ataxic Pogo mouse. To address this issue, we first describe the discovery of Pogo mouse and its morphological and behavioral defects. Then, we focus on the abnormal expression of several molecules in the Pogo cerebellum, including tyrosine hydroxylase, glutamate, corticotrophin-releasing factor, and 5-hydroxytryptamine. Much of this review is concerned with the functional implications of these ectopic molecules in the Pogo cerebellum.

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Acknowledgments

The authors express sincere gratitude to Seung-Hyuk Chung and Richard Hawkes for their helpful comments on this manuscript. Moreover, we appreciate Jin-Seung Kim, Jae-Min Kim, and Jin-A Son for their skillful technical assistance. This work was supported by Korean Research Foundation Grant (KRF-2004-042-E00002) funded by the Korean Government.

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  1. Department of Anatomy, College of Medicine, Konyang University, 685 Gasuwon-dong, Seo-gu, Daejeon, 302-718, South-Korea

    Nam-Seob Lee & Young-Gil Jeong

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  1. Nam-Seob Lee
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  2. Young-Gil Jeong
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Correspondence to Young-Gil Jeong.

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Lee, NS., Jeong, YG. Pogo: A Novel Spontaneous Ataxic Mutant Mouse. Cerebellum 8, 155–162 (2009). https://doi.org/10.1007/s12311-009-0096-6

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  • DOI: https://doi.org/10.1007/s12311-009-0096-6

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