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Secondary plasma cell leukaemia (PCL) with plasmablastic morphology

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Abstract

A 71-year-old female with relapsed IgA lambda myeloma developed progressive cytopenia. The peripheral blood film showed 5% blastoid cells. Flow cytometry analysis was indicative of plasma cells. The bone marrow smear was packed with plasmablasts. Target CD138-cell FISH and molecular karyotyping identified a complex genome. NGS identified high-risk mutations. Bone marrow histology confirmed myeloma with no evidence of acute leukaemia. The patient was diagnosed with plasmablastic progression of myeloma and secondary PCL. Secondary PCL patients have a poor prognosis. It is essential to recognize this subtype and explore a novel treatment approach.

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The data that support the findings of this study are available from the corresponding author upon reasonable request.

References

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Funding

The authors received no financial support for the research, authorship, and publication of this article.

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Authors and Affiliations

  1. Department of Haematology, University College London Hospitals NHS Foundation Trust, University College London, 250 Euston Road, London, NW1 2PG, UK

    Ke Xu

  2. Specialist Integrated Haematology Malignancy Diagnostic Service, Health Services Laboratories, University College London Hospitals NHS Foundation Trust, University College London, London, UK

    Ke Xu & Elisabeth Nacheva

  3. UCL School of Life and Medical Sciences, London, UK

    Elisabeth Nacheva

Authors
  1. Ke Xu
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  2. Elisabeth Nacheva
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Contributions

KX wrote up the manuscript. KX and EN critically revised the final version of the manuscript.

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Correspondence to Ke Xu.

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For this type of study, consent for publication is not required. No written or verbal consent obtained from patient. Patient has passed away.

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The authors declare no competing interests.

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Xu, K., Nacheva, E. Secondary plasma cell leukaemia (PCL) with plasmablastic morphology. J Hematopathol (2024). https://doi.org/10.1007/s12308-024-00583-w

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  • DOI: https://doi.org/10.1007/s12308-024-00583-w

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