Journal of Hematopathology

, Volume 11, Issue 2, pp 57–62 | Cite as

Leukemic mantle cell lymphoma and chronic lymphocytic leukemia: a rare composite lymphoma and literature review

  • Etan Marks
  • Cynthia Liu
  • Bruce Raphael
  • Arnaldo Arbini
Case Report


Composite lymphomas are rare entities that either represent a collision of two separate lymphomas, or one lymphoma that expresses two distinct phenotypes. Mantle cell lymphoma has been reported in some composite lymphomas, but when combined with chronic lymphocytic leukemia, it can be difficult to recognize because of the phenotypic overlap of these two entities. We report a case of a 75-year-old male with a slowly progressing lymphocytosis, but who was otherwise asymptomatic. Flow cytometry revealed two different populations, one showing bright Lambda positivity and CD5(+), while the other was positive for both lambda and kappa and was CD5(+). Subsequently, cytogenetics revealed two different populations, one with a trisomy 12 and the other with a t(11;14). Additionally, immunohistochemistry on a bone marrow biopsy showed SOX-11 to be negative and cyclin D1 to be positive on scattered lymphocytes. This was consistent with a composite lymphoma of leukemic mantle cell lymphoma and chronic lymphocytic lymphoma.


Composite lymphoma Mantle cell lymphoma Chronic lymphocytic leukemia Sox-11 Leukemic mantle cell lymphoma 


Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Informed consent from patient

Informed consent was received from the patient for this paper to be published.


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© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of PathologyNew York University Medical CenterNew YorkUSA
  2. 2.Hematology Division, Department of MedicineNew York University Medical CenterNew YorkUSA

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