Abstract
Aggressive natural killer cell leukemia/lymphoma (ANKL) is a rare and aggressive malignancy of natural killer (NK) cells. It is now regarded as a distinct subtype of leukemia as a provisional entity: “NK cell lymphoblastic leukemia/lymphoma” in the 2016 revision to the World Health Organization classification. It is important to diagnose ANKL early due to its fulminant clinical features that may rapidly progress to multiorgan failure (MOF). However, there is no definite diagnostic marker of the disease so it is difficult to make differential diagnosis from other lymphoproliferative disorders. The case reported here is of a 27-year-old male patient who initially presented with leukopenia, disseminated intravascular coagulation (DIC), and MOF during the early stages of illness, and a diagnosis of ANKL was made after a series of examinations. He had no opportunity to take chemotherapy due to the extremely short and aggressive disease course. To the best of our knowledge, this was the first case with ANKL reported from our hospital and the second case from Turkey.
Similar content being viewed by others
References
Fernandez LA, Pope B, Lee C, Zayed E (1986) Aggressive natural killer cell leukemia in an adult with establishment of an NK cell line. Blood 67(4):925–930
Arber DA, Orazi A, Hasserjian R, Thiele J, Borowitz MJ, Le Beau MM, Bloomfield CD, Cazzola M, Vardiman JW (2016) The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. Blood 127(20):2391–2405. https://doi.org/10.1182/blood-2016-03-643544
Ruskova A, Thula R, Chan G (2004 Dec) Aggressive natural killer-cell leukemia: report of five cases and review of the literature. Leuk Lymphoma 45(12):2427–2438. https://doi.org/10.1080/10428190400004513
Zhang H, Meng Q, Yin W, Xu L, Lie L (2013) Adult aggressive natural killer cell leukemia. Am J Med Sci 346(1):56–63. https://doi.org/10.1097/MAJ.0b013e3182764b59
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Yıldız, A., Şahin, O., Öztürk, Ç.P. et al. Rare aggressive natural killer cell leukemia presented with leukopenia and disseminated intravascular coagulation—a diagnostic challenge. J Hematopathol 11, 5–7 (2018). https://doi.org/10.1007/s12308-017-0313-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12308-017-0313-z