Abstract
Denis Nobel looks at four important misinterpretations of molecular biology concerning evolutionary processes and demonstrates that the new synthesis today looks rather outdated. The modern synthesis is nearly 80 years old. The proponents who worked out the modern synthesis had no access to the current knowledge on cell biology, genetics, epigenetics, RNA biology and virology. Therefore this contribution adds several aspects which Nobel’s article does not explicitly mention, providing some examples for a better understanding of evolutionary novelty.
References
Belfort, M., Curcio, M. J., & Lue, N. F. (2011). Telomerase and retrotransposons: Reverse transcriptases that shaped genomes. Proceedings of the National Academy of Sciences of the USA, 108(51), 20304–20310.
Cech, T. R., & Steitz, J. A. (2014). The noncoding RNA revolution-trashing old rules to forge new ones. Cell, 157(1), 77–94.
Flores, R., Gago-Zachert, S., Serra, P., Sanjuán, R., Elena, S., & F. (2014). Viroids: Survivors from the RNA world? Annual Reviews in Microbiology, 68, 395–414.
Gilbert, W. (1986). Origin of life: The RNA world. Nature 319, 618.
Hayden, E. J., & Lehman, N. (2006). Self-assembly of a group I intron from inactive oligo nucleotide fragments. Chemical Biology, 13, 909–918.
Higgs, P. G., & Lehman, N. (2015). The RNA world: Molecular cooperation at the origins of life. Nature Reviews Genetics, 16, 7–17.
Koonin, E. V. (2009). On the origin of cells and viruses: Primordial virus world scenario. Annals of the New York Academy of Sciences, 1178(1), 47–64.
Mattick, J. S. (2003). Challenging the dogma: The hidden layer of non-coding RNAs in complex organisms. BioEssays, 25, 930–939.
Mattick, J. S. (2009). Deconstructing the dogma: A new view of the evolution and genetic programming of complex organisms. Annals of the New York Academy of Sciences, 1178, 29–46.
Pastuzyn, E. D., Day, C. E., Kearns, R. B., Kyrke-Smith, M., Taibi, A. V., McCormick, J., Yoder, N., Belnap, D. M., Erlendsson, S., Morado, D. R., Briggs, J. A. G., Feschotte, C., & Shepherd, J. D. (2018). The neuronal gene arc encodes a repurposed Retrotransposon gag protein that mediates intercellular RNA transfer. Cell, 172(1–2), 275–288.
Rohwer, F., Youle, M., Maughan, H., & Hisakawa, N. (2014). Life in our phage world. A Centennial Field Guide to the Earth’s Most Diverse Inhabitants. Wholon.
Takemura, M. (2020). Medusavirus ancestor in a proto-eukaryotic cell: Updating the hypothesis for the viral origin of the nucleus. Frontiers in Microbiology, 11, 571831. https://doi.org/10.3389/fmicb.2020.571831.
Vaidya, N., Manapat, M. L., Chen, I. A., Xulvi-Brunet, R., Hayden, E. J., & Lehman, N. (2012). Spontaneous network formation among cooperative RNA replicators. Nature, 491(7422), 72–77.
Villarreal, L. P. (2015). Force for ancient and recent life: Viral and stem-loop RNA consortia promote life. Annals of the New York Academy of Sciences, 1341, 25–34.
Villarreal, L. P. (2016). Viruses and the placenta: The essential virus first view. APMIS, 124(1–2), 20–30.
Villarreal, L. P., & Witzany, G. (2013). The DNA habitat and its RNA inhabitants: At the Dawn of RNA sociology. Genomics Insights, 6, 1–12.
Villarreal, L. P., & Witzany, G. (2015). When competing viruses unify: Evolution, conservation, and plasticity of genetic identities. Journal of Molecular Evolution, 80(5–6), 305–318.
Villarreal, L. P., & Witzany, G. (2019). That is life: Communicating RNA networks from viruses and cells in continuous interaction. Annals of the New York Academy of Sciences, 1447, 5–20.
Witzany, G. (2006a). Natural genome-editing competences of viruses. Acta Biotheoretica, 54(4), 235–253.
Witzany, G. (2006b). Serial Endosymbiotic theory (set): The biosemiotic update. Acta Biotheoretica, 54(2), 103–117.
Witzany, G. (2009). Noncoding RNAs: Persistent viral agents as modular tools for cellular needs. Annals of the New York Academy of Sciences, 1178, 244–267.
Witzany, G. (2011). The agents of natural genome editing. Journal of Molecular Cell Biology, 3(3), 181–189.
Witzany, G. (2017). Two genetic codes: Repetitive syntax for active non-coding RNAs; non - repetitive syntax for the DNA archives. Communicative and Integrative Biology, 10, e1297352.
Witzany, G. (2020a) Evolution of genetic information without error replication. In M. Burgin, & G. Dodig-Crnkovic (Eds.), Theoretical information studies: Information in the world, pp. 295–320. World Scientific.
Witzany, G. (2020b). What is life? Frontiers in Astronomy and Space Sciences, 7, 7. https://doi.org/10.3389/fspas.2020.00007.
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Witzany, G. To the End of Dogmatism in Molecular Biology. Biosemiotics 14, 67–72 (2021). https://doi.org/10.1007/s12304-021-09411-5
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DOI: https://doi.org/10.1007/s12304-021-09411-5