Copper and Zinc Status in Psoriasis: Correlation with Severity

Abstract

Psoriasis is a common and an inflammatory skin disease. Trace elements play an important role in the skin metabolism such as keratinisation and melanin formation as well as immunological and inflammatory reactions. Henceforth, the present study was aimed to evaluate the essential metals with special reference to Cu and Zn. In this study, 72 psoriatic patients and 50 controls were enrolled. On the basis of PASI score psoriatic group comprising of 48 mild and 24 severe psoriatic patients were grouped. The serum trace elements analysis in the subjects revealed that serum Cu levels and Cu/Zn ratio was significantly higher in the psoriatic patients as compared to controls. Interestingly, severity of the psoriasis was well correlated with the serum Cu levels. Taking together, all these findings suggest that Cu may be a major culprit in the pathogenesis as well as in the severity of the disease.

This is a preview of subscription content, access via your institution.

Fig. 1

References

  1. 1.

    Tsoi LC, Spain SJ, Knight J, Trembath RC. Identification highlights the role of innate immunity. Nat Genet. 2012;12:1341–8.

    Article  Google Scholar 

  2. 2.

    Rickettes JR, Rothe MJ, Grant-kels JM. Nutrition and psoriasis. Clin Dermatol. 2010;28:615–26.

    Article  Google Scholar 

  3. 3.

    Naziruglu M, Yildiz K, Tamturk BJ, Erturn I, Flores-acre M. Selenium and psoriasis. Biol Trace Elem Res. 2012;150:3–9.

    Article  Google Scholar 

  4. 4.

    Osredkar J, Sustar N. Copper and zinc, biological role and significance of copper/zinc imbalance. J Clin Toxicol. 2011;53:001. https://doi.org/10.4172/2161-0495.s3-001.

    Article  Google Scholar 

  5. 5.

    Nistor N, Ciontu L, Streenga V. Acrodermatitis enteropathica. Medicine. 2016;95:e3553.

    Article  Google Scholar 

  6. 6.

    Dadras MS, Namazi N, Khalilazar S, Younespour S. Trace elements status in psoriasis and their relationship with the severity of the disease. Iran J Dermatol. 2012;15(60):38–41.

    Google Scholar 

  7. 7.

    Inesi Giuseppe. Molecular features of copper binding proteins involved in copper homeostasis. IUBMB Life. 2016;69(4):211–7.

    Article  Google Scholar 

  8. 8.

    Prasad R, Kaur G, Walia BNS. A critical evaluation of copper metabolism in Indian wilsons disease children with special reference to their phenotypes and relatives. Biol Trace Elem Res. 1998;65:153–65.

    CAS  Article  Google Scholar 

  9. 9.

    Mohamad NS. Trace elements homeostatic imbalance in mild and severe psoriasis: a new insight in biomarker diagnostic value for psoriasis. Our Dermatol Online. 2013;4(4):449–52.

    Article  Google Scholar 

  10. 10.

    Osredkar J, Sustar N. Copper and zinc, biological role and significance of copper/zinc imbalance. J Clin Toxicol. 2019;9(2):411.

    Google Scholar 

Download references

Acknowledgements

The authors highly appreciate Mr. Rajesh for his statistical assistance and to the department of Biochemistry as well as department of Dermatology, MMIMSR for providing research facilities.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Jyoti Aggarwal.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Aggarwal, J., Singh, A., Gupta, S. et al. Copper and Zinc Status in Psoriasis: Correlation with Severity. Ind J Clin Biochem 36, 120–123 (2021). https://doi.org/10.1007/s12291-019-00870-9

Download citation

Keywords

  • Psoriasis
  • Trace elements
  • Copper
  • Zinc
  • Oxidative stress
  • PASI score