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Polymorphisms of BIRC5 Gene is Associated with Chronic HBV Infection in Iranian Population

  • Original Research Article
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Abstract

Survivin can affect the progression of infection and is considered as a marker of various malignancies. The aim of the study was to investigate the possible association of gene polymorphisms of survivin (-1547A/G, -644C/T, -625 C/G, -241C/T, -31G/C, -141G/C) and chronic hepatitis B infection in Iranian patients. The genotypes of survivin SNPs were investigated by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) method using 100 chronic HBV infected patients (HBV), 40 spontaneously recovered HBV subjects and 100 healthy controls (C). Serum level of survivin was determined using ELISA method. The -1547G, -625C, -241T and -31C alleles were associated with increased susceptibility to chronic hepatitis B infection (P = 0.001, P < 0.001, P = 0.003 and P < 0.001 respectively). Chronic HBV patients with -625CC, -241TT and -31CC genotypes had higher levels of survvin. Survivin -1547A/G, -625 C/G, -241C/T and -31G/C gene polymorphisms may be associated with chronic HBV susceptibility in Iranian HBV patients.

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Abbreviations

SNP:

Single nucleotide polymorphisms

HBV:

Hepatitis B virus

SR:

Spontaneously recovered

PCR-RFLP:

Polymerase chain reaction restriction fragment length polymorphism

ELISA:

Enzyme-linked immunosorbent assay

IAPs:

Inhibitor of apoptosis family of proteins

BIRC5:

Baculoviral inhibitor of apoptosis repeat containing 5

RT-PCR:

Reverse transcription polymerase chain reaction

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Acknowledgements

The authors would like to thank all participants who willingly participated in this study. We appreciate all who helped us in this work, especially in the Blood Transfusion Research Center of Zahedan, Iran. This study was approved by the Institutional Ethics Committee of the Zahedan University of Medical Sciences (IR.ZAUMS.REC.1395.159, Grant Number 7868).

Funding

This project was supported by the vice chancellor of Research and Technology of Zahedan University of Medical Sciences (ZUMS) and Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences.

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Authors and Affiliations

  1. Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran

    Bita Moudi, Zahra Heidari & Hamidreza Mahmoudzadeh-Sagheb

  2. Department of Histology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

    Bita Moudi, Zahra Heidari & Hamidreza Mahmoudzadeh-Sagheb

Authors
  1. Bita Moudi
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  2. Zahra Heidari
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  3. Hamidreza Mahmoudzadeh-Sagheb
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Contributions

BM, ZH, HM-S conceived and co-designed the study, supervised all the experimental design, analyzed the results, and drafted the manuscript. All authors read, modified and approved the final version of the manuscript. These authors equally contributed to this work.

Corresponding author

Correspondence to Zahra Heidari.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was written and signed by all individual participants included in the study.

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Moudi, B., Heidari, Z. & Mahmoudzadeh-Sagheb, H. Polymorphisms of BIRC5 Gene is Associated with Chronic HBV Infection in Iranian Population. Ind J Clin Biochem 35, 158–168 (2020). https://doi.org/10.1007/s12291-018-0805-3

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  • DOI: https://doi.org/10.1007/s12291-018-0805-3

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