Indian Journal of Clinical Biochemistry

, Volume 33, Issue 4, pp 382–386 | Cite as

Serum Biomarker Based Algorithms in Diagnosis of Ovarian Cancer: A Review

  • Suchitra KumariEmail author
Review Article


Epithelial ovarian cancer accounts for more than 90% of ovarian tumours and continues as a leading cause of death from gynaecological malignancies. It is often difficult to differentiate a benign ovarian mass from malignant ones. Invasive histopathological biopsy is used as the gold standard diagnostic tool to diagnose cancer in patients with ovarian mass. A wide spectrum of Biomarkers were tried in various studies to develop a non invasive diagnostic tool, out of which HE4 and CA 125 remain the only clinically useful biomarker. Consequently various Biomarker based algorithms i.e. Risk of Malignancy Index, risk of ovarian cancer algorithm, OVA1, risk of malignancy algorithm were generated that have been developed to assess the risk of a mass being malignant. These algorithms help in timely triage of patients. Recently in 2016 FDA cleared Ova1 test (OVERA) with CA 125-II, HE4, apolipoprotein A-1, FSH, and transferring (Sensitivity 91% and Specificity 69%) as a referral or Triage test in patients presenting with ovarian mass. Combination of protein and circulating Micro RNA analysis in blood, could provide a comprehensive screening and diagnostic panel, in management of patients presenting with ovarian mass in one clinical setting.


Epithelial ovarian cancer Biomarkers Biomarker based algorithms Circulating Micro RNA 


Compliance with Ethical Standards

Conflict of interest

Author declares that they have no conflict of interest.

Ethical Approval

This article does not contain any studies with human participants or animals performed by the authors.

Human and Animal Right Statement

For this type of study formal consent is not required. This article does not contain any studies with human participants or animals performed by the authors.


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Copyright information

© Association of Clinical Biochemists of India 2018

Authors and Affiliations

  1. 1.Department of BiochemistryAll India Institute of Medical Sciences (AIIMS)Sijua, BhubaneswarIndia

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