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Indian Journal of Clinical Biochemistry

, Volume 33, Issue 2, pp 121–131 | Cite as

A Narrative Review of Potential Future Antidiabetic Drugs: Should We Expect More?

  • Gaurav Chikara
  • Pramod Kumar Sharma
  • Pradeep Dwivedi
  • Jaykaran Charan
  • Sneha Ambwani
  • Surjit Singh
Review Article

Abstract

Prevalence of diabetes mellitus, a chronic metabolic disease characterized by hyperglycemia, is growing worldwide. The majority of the cases belong to type 2 diabetes mellitus (T2DM). Globally, India ranks second in terms of diabetes prevalence among adults. Currently available classes of therapeutic agents are used alone or in combinations but seldom achieve treatment targets. Diverse pathophysiology and the need of therapeutic agents with more favourable pharmacokinetic-pharmacodynamics profile make newer drug discoveries in the field of T2DM essential. A large number of molecules, some with novel mechanisms, are in pipeline. The essence of this review is to track and discuss these potential agents, based on their developmental stages, especially those in phase 3 or phase 2. Unique molecules are being developed for existing drug classes like insulins, DPP-4 inhibitors, GLP-1 analogues; and under newer classes like dual/pan PPAR agonists, dual SGLT1/SGLT2 inhibitors, glimins, anti-inflammatory agents, glucokinase activators, G-protein coupled receptor agonists, hybrid peptide agonists, apical sodium-dependent bile acid transporter (ASBT) inhibitors, glucagon receptor antagonists etc. The heterogeneous clinical presentation and therapeutic outcomes in phenotypically similar patients is a clue to think beyond the standard treatment strategy.

Keywords

Diabetes mellitus type 2 Glimins mTOT agonists ASBT inhibitors Precision medicine 

Notes

Acknowledgements

All authors have contributed significantly to a collection of information and designing and formatting of the manuscript.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© Association of Clinical Biochemists of India 2017

Authors and Affiliations

  • Gaurav Chikara
    • 1
  • Pramod Kumar Sharma
    • 2
  • Pradeep Dwivedi
    • 2
  • Jaykaran Charan
    • 2
  • Sneha Ambwani
    • 2
  • Surjit Singh
    • 2
  1. 1.Dr. Sampurnanand Medical College-JodhpurJodhpurIndia
  2. 2.All India Institute of Medical Sciences (AIIMS)-JodhpurJodhpurIndia

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