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Putative Role of Cardio Metabolic Risk Among Poorly Controlled Asthmatics in South Indian Population

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Abstract

Mortality and morbidity attributed to asthma remains to be the biggest nightmare worldwide. Hence, the study was aimed to compare the cardio metabolic risk factors as assessed by Body mass index (BMI), waist hip ratio (WHR), serum triacylglycerol and uric acid in well controlled and poorly controlled asthmatics and to correlate these parameters with the severity of asthma. A case control study was conducted on 90 subjects who were segregated into well controlled asthmatics (n = 30) and poorly controlled asthmatics (n = 30) who were diagnosed based on Global initiative for Asthma management guidelines and healthy volunteers (n = 30). Centrifuged fasting venous blood samples were used for biochemical analysis, pulmonary function test, BMI, and waist hip ratio (WHR) were measured. The statistical analysis was done using SPSS version 17. There was a significant increase in BMI, WHR, lipid profile, serum uric acid and decrease in forced expiratory volume (FEV1), forced vital capacity (FVC), and FEV1/FVC in poorly controlled asthmatics. There was a significant association between FEV1 and serum uric acid, BMI and Triacylgycerol in poorly controlled asthmatics. Poorly controlled asthmatics have greater risk of developing cardiometabolic problems. Serum uric acid can be used as one of the severity markers in asthma to assess cardio metabolic risk.

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Acknowledgments

This study was funded by Indian Council of Medical Research—ICMR, New Delhi, India, under Short term studentship project. (Grant No: 2013-03225). Dr. Sethuraman. K. R, Vice-Chancellor, Dr. Ananthakrishnan. N, Dean Research and Allied Health Sciences and Dr. Ravi Shankar. M, Dean, Faculty of Medicine, Sri Balaji Vidyapeeth.

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Authors and Affiliations

  1. Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute Pillayarkuppam, Puducherry, 607402, India

    Murugaiyan Sathish Babu, K. P. Sreesoorya, Subiman Saha, A. R. Srinivasan, S. Arul Vijaya Vani, R. Reeta & V. Kuzhandai Velu

  2. Department of Pulmonary Medicine, Mahatma Gandhi Medical College and Research Institute Pillayarkuppam, Puducherry, 607403, India

    Surendra K. Menon

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  1. Murugaiyan Sathish Babu
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  2. K. P. Sreesoorya
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  3. Surendra K. Menon
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  4. Subiman Saha
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  5. A. R. Srinivasan
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  6. S. Arul Vijaya Vani
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  8. V. Kuzhandai Velu
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Correspondence to Murugaiyan Sathish Babu.

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Conflict of interest

SathishBabu Murugaiyan, K. P. Sreesoorya, Surendra K. Menon, SubimanSaha, Srinivasan AR, Arul Vijaya Vani. S, Reeta R, Kuzhandai Velu V, declare no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Present study was conducted after getting institute ethical clearance and consent from all the study subjects.

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Sathish Babu, M., Sreesoorya, K.P., Menon, S.K. et al. Putative Role of Cardio Metabolic Risk Among Poorly Controlled Asthmatics in South Indian Population. Ind J Clin Biochem 32, 225–229 (2017). https://doi.org/10.1007/s12291-016-0595-4

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  • DOI: https://doi.org/10.1007/s12291-016-0595-4

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