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Microalbuminuria in Obese Young and Middle Aged Population: A Potential Marker of Cardiovascular Risk

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Abstract

Microalbuminuria is an established cardiovascular risk indicator in diabetes, hypertension and the general population. There is lack of information on MAU in healthy obese Indian adults and an ongoing debate whether obese adults deserve targeted identification and clinical intervention for MAU and prediabetes. We aimed to screen the healthy obese, young (group I) and middle aged (group II) adults for prevalence of MAU and prediabetes and study its association with Framingham risk score. The study included 50 healthy obese young (20–30 years) and middle aged adults (31–50 years), attending the outpatient clinic of Dept. of Medicine for a duration of 2 months (July–August). The patients were screened for fasting blood sugar, lipid profile and MAU. Of the total patients 28 % had MAU, 32.14 % of which had prediabetes and 33.33 % had diabetes whereas 10 % were normoglycemic. The group I patients had 50 % cases of MAU and group II had 25 % patients with MAU. Group II 63.63 % pre-diabetics. The values of MAU obtained were correlated with age, gender, body mass index, systolic and diastolic blood pressure, FBS, waist to hip ratio using Pearson’s Coefficient (p < 0.05). The 10 year CVD risk calculated using FRS in subjects with MAU was higher as compared to those without MAU. Thus we conclude that Indian, young and middle aged obese adults to be at a risk of prediabetes, MAU and CV risk warranting their routine screening for better clinical outcomes.

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Acknowledgments

The project was awarded the Short term studentship—Indian Council of Medical Research (STS-ICMR) for the year 2014–15.

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Authors and Affiliations

  1. Department of Biochemistry, AIIMS Jodhpur, Jodhpur, India

    Purvi Purohit, Shailendra Dwivedi & Praveen Sharma

  2. AIIMS Jodhpur, Jodhpur, India

    Kunal Garg

  3. Department of Medicine, AIIMS Jodhpur, Jodhpur, India

    Vikram Singh

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  1. Purvi Purohit
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  2. Kunal Garg
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  3. Vikram Singh
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  4. Shailendra Dwivedi
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  5. Praveen Sharma
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Correspondence to Purvi Purohit.

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Conflict of interest

Purvi Purohit, Kunal Garg, Vikram Singh, Shailendra Dwivedi and Praveen Sharma declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Human and Animal Rights

This article does not contain any studies with animals performed by any of the authors.

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Informed consent was obtained from all individual participants included in the study.

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Purohit, P., Garg, K., Singh, V. et al. Microalbuminuria in Obese Young and Middle Aged Population: A Potential Marker of Cardiovascular Risk. Ind J Clin Biochem 31, 349–352 (2016). https://doi.org/10.1007/s12291-016-0563-z

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  • DOI: https://doi.org/10.1007/s12291-016-0563-z

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