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Indian Journal of Clinical Biochemistry

, Volume 31, Issue 4, pp 402–413 | Cite as

Methylenetetrahydrofolate Reductase C677T Polymorphism and Recurrent Pregnancy Loss Risk in Asian Population: A Meta-analysis

  • Vandana RaiEmail author
Original Article

Abstract

The C677T polymorphism of the methylenetetrahydrofolate reductase (MTHFR) gene was implicated to be associated with thrombophilia due to its role in catalyzing the formation of 5-methylenetetrahydrofolate, a co-substrate for the conversion of homocysteine to methionine. Several case–control studies were investigated MTHFR C677T polymorphism as risk for recurrent pregnancy loss (RPL). These studies rendered contradictory results, some indicating that the polymorphism is associated with the risk of RPL whereas others concluded there is no association. To shed light on these inconclusive findings, a meta-analysis of all available studies published from Asian population relating the C677T polymorphism to the risk of RPL was conducted. The following electronic databases were searched without language restrictions: PubMed, Google Scholars, Elsevier and Springer Link up to December, 2015. Meta-analysis was performed using MetaAnalyst and Mix version 1.7. Meta-analysis results suggested that MTHFR C677T polymorphism contributed to the increased RPL risk in Asian population using all five genetic models (for T vs. C: OR 1.35, 95 % CI 1.09–1.68, p = 0.009; for TT + CT vs. CC: OR 1.44, 95 % CI 1.14–1.82, p = 0.006; for CT vs. CC: OR 1.39, 95 % CI 1.07–1.8, p = 0.01; for TT vs. CC: OR 1.79, 95 % CI 1.23.2.6, p = 0.007; for TT vs. CT + CC: OR 1.61, 95 % CI 1.02–2.56, p = 0.04). In conclusion, this meta-analysis demonstrates a strong association between the MTHFR C677T variant and RPL in Asian population and raising the importance of the use of folate in its treatment and prevention.

Keywords

Recurrent pregnancy loss Thrombophilic gene MTHFR C677T Meta-analysis Folate 

Notes

Acknowledgments

The author is highly grateful to Leon Bax (Chief Scientific Officer at BiostatXL, UMC Utrecht) for his valuable suggestions, which help her in statistical analysis.

Compliance with Ethical Standards

Conflict of interest

None.

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© Association of Clinical Biochemists of India 2016

Authors and Affiliations

  1. 1.Human Molecular Genetics Laboratory, Department of BiotechnologyVBS Purvanchal UniversityJaunpurIndia

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