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Association of Elevated Serum Lipoprotein(a), Inflammation, Oxidative Stress and Chronic Kidney Disease with Hypertension in Non-diabetes Hypertensive Patients

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Abstract

Hypertension is the most common cardiovascular risk factor. Lipoprotein(a) [Lp(a)], inflammation, oxidative stress and chronic kidney disease (CKD) exacerbate the response to tissue injury and acts as markers of the vascular disease, especially in glomerulosclerosis. We compared the clinical characteristics of 138 non-diabetes hypertensive women (ndHT) patients with 417 non-diabetes normotensive subjects and tested the association of hypertension with Lp(a), inflammation, CKD and oxidative stress by using multiple logistic regression. BP, BMI, waist circumference, creatinine, Lp(a), inflammation and malondialdehyde levels were significantly higher and CKD state in the ndHT patients (p < 0.05). Multiple logistic regression showed hypertension associated with increased Lp(a), inflammation, ORs and 95 % CIs were 2.52 (1.33, 4.80), 2.75 (1.44, 5.27) after adjusting for their covariates. Elevated serum Lp(a) and inflammation levels concomitants with increased oxidative stress and CKD were the major risk factors associated with hypertension and implications for the increased risk of HT and vascular disease.

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Acknowledgments

We sincerely thank Naresuan University and The Phitsanulok Provincial for financial support and also thank Mr. Sarawut Kooburat, MS Tientip Jankaet, and all co-workers for their blood collection and technical assistance. We sincerely thank who the patients participated in this study and Asst. Prof. Dr. Ronald A. Markwardt, Faculty of Public Health, Burapha University, for his critical reading and correcting of the manuscript.

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Authors and Affiliations

  1. Chronic Disease Research Unit, Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, 65000, Thailand

    Surapon Tangvarasittichai & Orathai Tangvarasittichai

  2. Department of Community Occupational Family Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand

    Patcharin Pingmuanglaew

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  1. Surapon Tangvarasittichai
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  2. Patcharin Pingmuanglaew
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Correspondence to Surapon Tangvarasittichai.

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Tangvarasittichai, S., Pingmuanglaew, P. & Tangvarasittichai, O. Association of Elevated Serum Lipoprotein(a), Inflammation, Oxidative Stress and Chronic Kidney Disease with Hypertension in Non-diabetes Hypertensive Patients. Ind J Clin Biochem 31, 446–451 (2016). https://doi.org/10.1007/s12291-016-0553-1

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  • DOI: https://doi.org/10.1007/s12291-016-0553-1

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