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Evaluation of Serum Vitamin B12 Levels and Its Correlation with Anti-Thyroperoxidase Antibody in Patients with Autoimmune Thyroid Disorders

Indian Journal of Clinical Biochemistry volume 30, pages 217–220 (2015)Cite this article

Abstract

Vitamin B12 deficiency has been reported in patients with Autoimmune thyroid disorders. However there is limited data on exact prevalence of low B12 and its correlation with anti-thyroperoxidase antibody (anti-TPO) levels in these patients. The aim of our study was to estimate serum vitamin B12 levels in autoimmune thyroid disorders and to correlate B12 levels with anti-TPO. 350 patients were selected by convenient sampling. Vitamin B12 levels and thyroid parameters were estimated using fully automated chemiluminescence method on Access 2. Results of our study shows that using the manufacturer’s cut-off of 145 pg/mL, the prevalence of low serum vitamin B12 was found to be 45.50 %. Higher prevalence (55 %) was seen based on the published cut-off of 200 pg/mL The study however did not demonstrate any significant correlation between vitamin B12 levels and anti-TPO (r = −0.11 and p value of 0.30).

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Acknowledgments

The authors would like to thank the Research Society, St John’s Medical College Hospital for providing the grant for the study.

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Authors and Affiliations

  1. Department of Biochemistry, St John’s Medical College and Hospital, Bangalore, India

    S. Jaya Kumari & Anitha Devanath

  2. Department of Endocrinology, St John’s Medical College and Hospital, Bangalore, India

    Ganapathy Bantwal, Vageesh Aiyyar & Madhuri Patil

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  1. S. Jaya Kumari
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  2. Ganapathy Bantwal
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  3. Anitha Devanath
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  4. Vageesh Aiyyar
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  5. Madhuri Patil
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Correspondence to S. Jaya Kumari.

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Jaya Kumari, S., Bantwal, G., Devanath, A. et al. Evaluation of Serum Vitamin B12 Levels and Its Correlation with Anti-Thyroperoxidase Antibody in Patients with Autoimmune Thyroid Disorders. Ind J Clin Biochem 30, 217–220 (2015). https://doi.org/10.1007/s12291-014-0418-4

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  • DOI: https://doi.org/10.1007/s12291-014-0418-4

Keywords

  • Vitamin B12
  • Autoimmunity
  • Auto antibodies
  • Autoimmune thyroid disorders (AITD)
  • Anti-thyroperoxidase (anti-TPO)