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Indian Journal of Clinical Biochemistry

, Volume 30, Issue 1, pp 72–77 | Cite as

Antidyslipidemic Effect of Ocimum sanctum Leaf Extract in Streptozotocin Induced Diabetic Rats

  • Ishrat Husain
  • Ramesh Chander
  • Jitendra Kumar Saxena
  • Abbas Ali Mahdi
  • Farzana MahdiEmail author
Original Article

Abstract

The antidyslipidemic activity of Ocimum sanctum leaf extract was studied in streptozotocin induced diabetic rats. In this model, there was significant increase in plasma markers of diabetic-dyslipidemia following diminution of lipid metabolizing enzymes. Oral administration of leaf extract (500 mg/kg b.w.p.o.) for 15 days resulted in significant decrease in diabetogenic and dyslipidemia parameters; namely blood glucose, glycosylated hemoglobin, lipid peroxide, free fatty acids, small dense low density lipoprotein, lipid and protein components of plasma lipoproteins, adipose and liver. The regulation of lipids was accompanied by stimulation of postheparin lipolytic activity, reactivation of lecithin cholesterol acyl transferase and hepatic lipoprotein lipase enzymes. The results of the present study demonstrated antidyslipidemic and antioxidant activities in leaf extract of O. sanctum which could be used in prevention of diabetic-dyslipidemia and related complications.

Keywords

Ocimum sanctum Anti-dyslipidemic agent Natural antioxidants Postheparin lipolytic activity Streptozotocin induced-diabetes Hypoglycemic agent 

Notes

Acknowledgments

The author is thankful to Indian Council of Medical Research, New Delhi for financial support vide project sanction No. 45/37/2009/BMS/TRM, dated 22/12/2009.

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Copyright information

© Association of Clinical Biochemists of India 2014

Authors and Affiliations

  • Ishrat Husain
    • 1
  • Ramesh Chander
    • 1
  • Jitendra Kumar Saxena
    • 2
  • Abbas Ali Mahdi
    • 3
  • Farzana Mahdi
    • 1
    Email author
  1. 1.Department of BiochemistryEra’s Lucknow Medical College & HospitalLucknowIndia
  2. 2.Division of BiochemistryCentral Drug Research InstituteLucknowIndia
  3. 3.Department of BiochemistryKing George’s Medical UniversityLucknowIndia

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