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Serum Paraoxonase (PON1) Activity in North-West Indian Punjabi’s with Acute Myocardial Infarction

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Abstract

Human serum paraoxonase-1 (PON1), an enzyme on HDL prevents oxidation of LDL thereby preventing the development of atherosclerosis. Studies done so far have lead to conflicting results. As studies are lacking in North-West Indian Punjabi’s, a distinct ethnic group with high incidence of coronary artery disease, we determined PONase activity in this population. It has been postulated that sudden lowering of serum PONase may lead to precipitation of acute myocardial infarction. We determined serum PONase activity and lipids in 100 patients each of AMI (within 24 h of onset), stable CAD and 100 age and sex matched healthy controls. These were again determined after 6 weeks in AMI patients. The mean serum PONase activity was lowest in AMI patients (23.26 U/ml) followed by stable CAD patients (102.0 U/ml) where as in controls was highest (179.8 U/ml). In patients with AMI, activity was significantly higher at 6 weeks as compared to that after acute event (49.39 %; p < 0.05). Sudden lowering of serum PONase activity in a population which already has lower activity may be one of the risk factors for development of AMI.

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Abbreviations

PONase:

Paraoxonase-1

CAD:

Coronary artery disease

AMI:

Acute myocardial infarction

HDL-C:

High density lipoprotein cholesterol

LDL-C:

Low density lipoprotein cholesterol

T-CHO:

Total-cholesterol

TG:

Triglycerides

SBP:

Systolic blood pressure

DBP:

Diastolic blood pressure

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Acknowledgments

The study was carried out at Department of Biochemistry, PGIMER, Chandigarh, India. We are grateful to the volunteers involved in the study, laboratory staff and all those who contributed in terms of time and effort.

Contribution

Author contribution conceived and design the experiments: VNM, NG, KDG and SS. Performed the experiment: NG. Analyzed the data: NG. Contributed reagents/materials/analysis tools: KDG and YSP. Wrote the paper: NG, VNM, SS and KDG. Editing: VNM, NG, GG, SS and KDG.

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Authors and Affiliations

  1. Department of Internal Medicine, Postgraduate Institute of Medical Education and Research, 4th Floor, Block F, Room 16, Nehru Hospital, Chandigarh, 160012, INDIA

    V. Nagarjuna Maturu & Surjit Singh

  2. Department of Biochemistry, PGIMER, Chandigarh, India

    Nidhi Gupta & Kirandip Gill

  3. Department of Cardiology, PGIMER, Chandigarh, India

    Gagandip Singh & Yash Paul Sharma

Authors
  1. V. Nagarjuna Maturu
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  2. Nidhi Gupta
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  3. Gagandip Singh
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  4. Kirandip Gill
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  5. Yash Paul Sharma
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  6. Surjit Singh
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Corresponding author

Correspondence to Surjit Singh.

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Maturu, V.N., Gupta, N., Singh, G. et al. Serum Paraoxonase (PON1) Activity in North-West Indian Punjabi’s with Acute Myocardial Infarction. Ind J Clin Biochem 28, 248–254 (2013). https://doi.org/10.1007/s12291-012-0260-5

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  • DOI: https://doi.org/10.1007/s12291-012-0260-5

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