Indian Journal of Clinical Biochemistry

, Volume 28, Issue 2, pp 181–184 | Cite as

Circadian Rhythm of Serum Cortisol in Female Patients with Fibromyalgia Syndrome

  • Ghizal Fatima
  • Siddharth Kumar Das
  • Abbas Ali MahdiEmail author
  • Nar Singh Verma
  • Faizan Haider Khan
  • Amit Mani Kumar Tiwari
  • Tabrez Jafer
  • Baby Anjum
Original Article


Fibromyalgia syndrome (FMS) patients have disturbed sleep patterns which may lead to altered circadian rhythm in serum cortisol secretion. The aim of this study was to assess circadian changes, if any, in serum cortisol levels in female patients with FMS. Cortisol levels were estimated every 6 h during 24 h period; in 40 female patients satisfying ACR criteria for FMS (Age 36.4 ± 9.9), and 40 healthy females without FMS (Age 33.8 ± 11.1). A significant difference in the night time serum cortisol level was observed among the patients and control groups (patients, 12.9 ± 9.7 controls 5.8 ± 3.0; p < 0.01). However, no significant difference was found in serum cortisol levels in patients and control groups in the morning (patients, 28.4 ± 13.2 controls, 27.6 ± 14.5; p > 0.05), afternoon (patients, 14.4 ± 5.6 controls, 14.0 ± 6.6; p > 0.05) and evening hours (patients, 10.9 ± 5.8 controls, 8.9 ± 3.6; p > 0.05). It could be concluded that there is an abnormality in circadian secretion of cortisol in female FMS patients.


Fibromyalgia syndrome Cortisol Circadian rhythm American College of Rheumatology Criteria 





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Copyright information

© Association of Clinical Biochemists of India 2012

Authors and Affiliations

  • Ghizal Fatima
    • 1
  • Siddharth Kumar Das
    • 1
  • Abbas Ali Mahdi
    • 2
    Email author
  • Nar Singh Verma
    • 3
  • Faizan Haider Khan
    • 4
  • Amit Mani Kumar Tiwari
    • 5
  • Tabrez Jafer
    • 5
  • Baby Anjum
    • 5
  1. 1.Department of RheumatologyKing George’s Medical UniversityLucknowIndia
  2. 2.Medical Elementology and Free Radical Biology Lab, Department of BiochemistryKing George’s Medical UniversityLucknowIndia
  3. 3.Department of PhysiologyKing George’s Medical UniversityLucknowIndia
  4. 4.Department of ZoologyLucknow UniversityLucknowIndia
  5. 5.Department of BiochemistryKing George’s Medical UniversityLucknowIndia

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