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Correlation of Cord Blood Lipid Heterogeneity in Neonates with Their Anthropometry at Birth

Indian Journal of Clinical Biochemistry volume 28, pages 152–157 (2013)Cite this article

Abstract

Objective: Fetus with intrauterine stress may exhibit programmed changes that can alter its metabolism and bear severe risk for diseases in adult life. The current study was designed to assess the correlation between cord blood lipid profile with the anthropometric data in neonates. Materials and methods: 146 newborn babies born at Dr. T M A Pai Hospital, Udupi were screened and their birth weight, length, head circumference and abdominal circumference were noted at birth. Umbilical cord blood samples were analyzed for total cholesterol, triglycerides (TG), high density lipoprotein (HDL) and low density lipoprotein (LDL). Infants were also grouped further based on gestational age (GA) and sex-adjusted birth weight percentiles into three groups i.e. Small for gestational age (SGA), Appropriate for gestational age (AGA) and Large for gestational age (LGA) for comparison of their lipid profiles. Inclusion criteria were normal fetal heart rate at birth and an APGAR score >7. Statistical significance of relation between lipid profile and anthropometry was done using ANOVA and Pearson correlation coefficient. Results: Triglycerides were significantly higher in babies with higher ponderal index (PI) than those with lower PI (P = 0.011). The TG level of SGA babies were significantly higher as compared to AGA group (P = 0.001). The LDL levels in neonates with higher abdominal circumference were significantly lower than those with lower AC (P = 0.019). Mean HDL levels were higher in neonates with larger AC, but not statistically significant. Maternal BMI had no influence on neonates’ lipid profile. Conclusion: Abnormal intrauterine milieu created by maternal changes during gestation may bear a profound impact on lipid metabolism in neonates, which may account for their differences in lipid profile and anthropometry at birth.

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References

  1. Kelishadi R, Badiee Z, Adeli K. Cord blood lipid profile and associated factors: baseline data of a birth cohort study. Paediatr Perinat Epidemiol. 2007;21(6):518–24.

    PubMed  Article  Google Scholar 

  2. Yonezawa R, Okada T, Kitamura T, Fujita H, Inami I, Makimoto M, Hosono S, Minato M, Takahashi S, Mugishima H, Yamamoto T, Masaoka N. Very low-density lipoprotein in the cord blood of preterm neonates. Metabolism. 2009;58(5):704–7.

    PubMed  Article  CAS  Google Scholar 

  3. Godfrey KM, Barker DJP. Fetal nutrition and adult disease. Am J Clin Nutr. 2000;71(suppl):1344S.

    PubMed  CAS  Google Scholar 

  4. Prado CG, Geloneze C, Tambascia MA, Barosfilho AA. Atherogenic profile of Brazilian near term newborns. Braz J Med Biol Res. 2005;38:755–60.

    Article  Google Scholar 

  5. Ophir E. Cord blood lipid concentration and their relation to body size at birth: possible link between intrauterine life and adult diseases. Am J Perinatol. 2004;21:35–40.

    PubMed  Article  Google Scholar 

  6. Fosbrooke AS, Wharton BA. Plasma lipids in umbilical cord blood from infants of normal and low birth weight. Biol Neonate. 1973;23:330–8.

    Article  Google Scholar 

  7. Kozuchowska P. Evaluation of lipids and apolipoproteins concentrations in cord blood serum of newborns from rural and urban environments. Ann Agric Environ Med. 2007;14(1):25–9.

    Google Scholar 

  8. Li J, Wang ZN, Schlemm L, Pfab T, Xiao XM, Chen YP, Hocher B. Low birth weight and elevated head-to-abdominal circumference ratio are associated with elevated fetal glycated serum protein concentrations. J Hypertens. 2011;29(9):1712–8.

    PubMed  Article  CAS  Google Scholar 

  9. Huter O, Brezinka C, Drexel H, Patsch JR. Cord blood lipids and lipoproteins in small-, appropriate-, and large-for-gestational age neonates born to non-diabetic mothers. J Matern Fetal Invest. 1997;7:172–4.

    Google Scholar 

  10. Baker DJP, Martyn CN, Osmond C, Hales CN, Fall CHD. Growth in utero and serum cholesterol concentration in adult life. BMJ. 1993;307:1524–7.

    Article  Google Scholar 

  11. Gunes T, Koklu E, Ozturk MA. Maternal and cord serum lipid profiles of preterm infants with respiratory distress syndrome. J Perinatol. 2007;27(7):415–21.

    PubMed  Article  CAS  Google Scholar 

  12. Merzouk H, Madani S, Prost J, Loukidi B, Meghelli-Bouchenak M, Belleville J. Changes in serum lipid and lipoprotein concentrations and compositions at birth and after 1 month of life in macrosomic infants of insulin-dependent diabetic mothers. Eur J Pediatr. 1999;158:750–6.

    PubMed  Article  CAS  Google Scholar 

  13. Merzouk H, Meghelli-Bouchenak M, el-Korso N, Belleville J, Prost J. Low birth weight at term impairs cord serum lipoprotein compositions and concentrations. Eur J Pediatr. 1998;157:321–6.

    PubMed  Article  CAS  Google Scholar 

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Affiliations

  1. Department of Biochemistry, Melaka Manipal Medical College (Manipal Campus), Manipal University, Udupi, Manipal, 576104, Karnataka, India

    Chandrika D. Nayak

  2. Kasturba Medical College, Manipal University, Manipal, 576104, Karnataka, India

    Vaibhav Agarwal

  3. Dr TMA Pai Hospital & Melaka Manipal Medical College (Manipal Campus), Manipal University, Manipal, 576104, Karnataka, India

    Dinesh M. Nayak

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  1. Chandrika D. Nayak
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  2. Vaibhav Agarwal
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  3. Dinesh M. Nayak
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Correspondence to Chandrika D. Nayak.

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Nayak, C.D., Agarwal, V. & Nayak, D.M. Correlation of Cord Blood Lipid Heterogeneity in Neonates with Their Anthropometry at Birth. Ind J Clin Biochem 28, 152–157 (2013). https://doi.org/10.1007/s12291-012-0252-5

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  • DOI: https://doi.org/10.1007/s12291-012-0252-5

Keywords

  • Anthropometry
  • Cord blood
  • Lipid profile