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Age-Related Changes of Serum Soluble Interleukin 9 Receptor (sIL-9Rα) in Healthy Subjects

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Abstract

Most cytokine receptors including interleukin (IL)-9 have soluble counterparts in body fluids. We planned to investigate the pathophysiological significance of the serum soluble IL-9 receptor (sIL-9R) level. We determined the serum sIL-9Rα chain (sIL-9Rα) levels in 96 healthy Japanese individuals to establish a control value by means of specific human sIL-9Rα ELISA, followed by a preliminary application in a patient with diarrhea positive hemolytic uremic syndrome. Age was negatively correlated with the sIL-9Rα level (Spearman r = −0.241, n = 96, p = 0.0180). The serum sIL-9Rα level showed a progressive decline to the normal adult level by the age of 30. The serum sIL-9Rα level of the patient with HUS was markedly higher than those of the age-matched control from the onset of the disease. Because of the remarkable age-dependent variability of sIL-9Rα in healthy subjects, disease-related changes, as well as therapy-dependent alterations, should be considered with caution. Thus, it is recommended that when the serum sIL-9Rα levels of patients are evaluated, the values should be compared with those of age-matched controls. The established control value will be used to discriminate between normal and the pathological conditions in our future studies.

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The authors declared no financial or commercial conflict of interest.

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Authors and Affiliations

  1. Laboratory of Immunology and Microbiology, Faculty of Pharmacy, Chiba Institute of Science, 3 Shiomi-cho, Choshi, Chiba, 288-0025, Japan

    Yoshihiro Okamoto, Mayuri Tanaka, Asami Kasahara, Takazumi Hara, Takashi Fukui & Toshiyuki Masuzawa

  2. Department of Pediatrics, Nagoya Daini Red Cross Hospital, 2-9 Myoken-cho, Showa-ku, Nagoya, Aichi, 466-8650, Japan

    Yoshimitsu Gotoh

  3. Department of Pediatrics, Seirei Hamamatsu General Hospital, 2-12-12 Sumiyoshi, Naka-ku, Hamamatsu, Shizuoka, 430-8558, Japan

    Naoya Fujita

Authors
  1. Yoshihiro Okamoto
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  2. Mayuri Tanaka
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  3. Asami Kasahara
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  4. Takazumi Hara
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  5. Yoshimitsu Gotoh
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  6. Naoya Fujita
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  7. Takashi Fukui
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  8. Toshiyuki Masuzawa
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Correspondence to Yoshihiro Okamoto.

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Okamoto, Y., Tanaka, M., Kasahara, A. et al. Age-Related Changes of Serum Soluble Interleukin 9 Receptor (sIL-9Rα) in Healthy Subjects. Ind J Clin Biochem 27, 400–404 (2012). https://doi.org/10.1007/s12291-012-0216-9

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  • DOI: https://doi.org/10.1007/s12291-012-0216-9

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