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Lack of Circadian Pattern of Serum TNF-α and IL-6 in Patients with Fibromyalgia Syndrome

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Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

The present study was designed to test the hypothesis of a circadian variation in circulating levels of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in women with fibromyalgia syndrome (FMS). Serum levels of IL-6 and TNF-α were measured at 4 h intervals of the day in 50 women with FMS satisfying American College of Rheumatology criteria for FMS (age 36.68 ± 9.89) as well as 50 healthy control women (age 32.82 ± 10.53). Serum TNF-α levels were substantially increased in patients with FMS but showed no circadian variation. In contrast, no difference in the levels of IL-6 was found. Moreover, there was also no circadian variation in both the groups of patients and controls. We conclude that no circadian pattern exists in the circulating levels of serum IL-6 and TNF-α in patients with FMS, although TNF-α levels are found raised in patients with FMS.

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Acknowledgments

Financial support to this work was provided by the Council of science and technology, Uttar Pradesh, Lucknow, India. (Grant No. CST/SERPD/D-1884/2008).

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Authors and Affiliations

  1. Department of Rheumatology & Biochemistry, Chhatrapati Shahuji Maharaj Medical University, Lucknow, India

    Ghizal Fatima, Siddharth Kumar Das, Puneet Kumar & Ragini Shrivastava

  2. Department of Biochemistry, Chhatrapati Shahuji Maharaj Medical University, Lucknow, India

    Ghizal Fatima, Abbas Ali Mahdi & Baby Anjum

  3. Department of Physiology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, India

    Nar Singh Verma

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  1. Ghizal Fatima
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  2. Abbas Ali Mahdi
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  3. Siddharth Kumar Das
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Correspondence to Abbas Ali Mahdi.

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Fatima, G., Mahdi, A.A., Das, S.K. et al. Lack of Circadian Pattern of Serum TNF-α and IL-6 in Patients with Fibromyalgia Syndrome. Ind J Clin Biochem 27, 340–343 (2012). https://doi.org/10.1007/s12291-012-0205-z

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  • DOI: https://doi.org/10.1007/s12291-012-0205-z

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