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Estimated Creatinine Clearance, Homocysteine and High Sensitivity-C-Reactive Protein Levels Determination for Early Prediction of Nephropathy and Atherosclerosis Risk In Type 2 Diabetic Patients

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Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

Type 2 diabetes mellitus (T2D) patients are increased risk for cardiovascular disease (CVD) and chronic kidney disease (CKD). Many studies had demonstrated that CKD is significantly associated with CVD. We aim to indicate the using estimated creatinine clearance (eCrCl), homocysteine (tHcy), and high sensitivity-C-reactive protein (hs-CRP) levels, may have an impact on the interpretation risk for nephropathy and CVD. eCrCl was using the Cockroft-Gault formula, eCrCl levels were stratified according to the Kidney Disease Outcome Quality Initiative definition. We measured serum tHcy, hs-CRP, and the other biochemical variables in 54 T2D patients compared with 40 age matched healthy controls (NDM). T2D patients were significantly lower eCrCl than NDM (P < 0.05). T2D patients also showed significantly higher in tHcy, hs-CRP, and MDA levels than NDM subjects (P < 0.05). The eCrCl was significantly correlated with tHcy and hs-CRP levels in T2D patients (r = −0.504, P < 0.001; r = −0.282, P = 0.047). eCrCl had an impact on interpretation for CKD, especially in T2D patients. Decrease eCrCl concomitant with increased in tHcy, hs-CRP, and MDA levels may present a higher risk for future diabetic nephropathy and CVD.

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Abbreviations

T2D:

Type 2 diabetes mellitus

CVD:

Cardiovascular disease

CKD:

Chronic kidney disease

eCrCl:

Estimated creatinine clearance

tHcy:

Homocysteine

hs-CRP:

High sensitivity-C-reactive protein

RI:

Renal insufficiency

RF:

Renal failure

Glu:

Glucose

TC:

Total cholesterol

TG:

Triglycerides

HDL-C:

High density lipoprotein-cholesterol

LDL-C:

Low density lipoprotein-cholesterol

KDOQI:

Kidney disease outcome quality initiative

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Acknowledgments

This study was funded by research grants from the Faculty of Allied Health Sciences, Naresuan University. We wish to thank Dr. Viruch Sirigulsatien, MD for his kindness suggestion, and Ms Suwadee Meemark, for their technical assistance. We particularly thank who the patients participated in this study. We sincerely thank Dr. Norman Scholfield Department of Physiology, Faculty of Medical Sciences, Naresuan University for their critical reading and correction of the manuscript.

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Authors and Affiliations

  1. Chronic Disease Research Unit, Department of Medical Technology, Faculty of Allied Health Sciences, Naresuan University, Phitsanulok, Thailand, 65000

    Suwipar Deebukkhum, Orathai Tangvarasittichai & Surapon Tangvarasittichai

  2. Department of Community Occupational Family Medicine, Faculty of Medicine, Naresuan University, Phitsanulok, Thailand

    Patchanrin Pingmuangkaew

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  1. Suwipar Deebukkhum
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  2. Patchanrin Pingmuangkaew
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Correspondence to Surapon Tangvarasittichai.

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Deebukkhum, S., Pingmuangkaew, P., Tangvarasittichai, O. et al. Estimated Creatinine Clearance, Homocysteine and High Sensitivity-C-Reactive Protein Levels Determination for Early Prediction of Nephropathy and Atherosclerosis Risk In Type 2 Diabetic Patients. Ind J Clin Biochem 27, 239–245 (2012). https://doi.org/10.1007/s12291-012-0192-0

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  • DOI: https://doi.org/10.1007/s12291-012-0192-0

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