Skip to main content

Advertisement

SpringerLink
Log in

Fibrinogen, Lp(a), Microalbuminuria and Left Ventricular Mass Index: Cardiovascular Disease Risk factors in Diabetes

  • Original Article
  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

The present work was undertaken to study interrelation of Fibrinogen, Lp(a) and LVMI in Type II diabetes patients with or without nephropathy. 100 Type II Diabetic patients attending OPD/IPD of DMC&H, Ludhiana were included. They were divided in two groups. Group I: 50 patients without microalbuminuria (MAU). Group II: 50 patients with MAU. Fibrinogen (Clauss method), Lp(a) and MAU were estimated on Multichannel Autoanalyzer Hitachi-911 (Roche). LVMI was estimated by echocardiography using formula of Devereux and Reicheck. Type II diabetes patients with MAU had significantly raised levels of Fibrinogen, Lp(a), and LVMI as compared to normoalbuminuric diabetics (P < 0.01). Group II patients had positive correlation between Lp(a) and LVMI but no relation between Fibrinogen and LVMI. MAU, marker of microangiopathy, is associated with higher Fibrinogen and Lp(a) levels. This becomes basis of increase cardiovascular risk as demonstrated by higher mean LVMI in Group II patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Evans JM, Wang J, Morris AD. Comparison of cardiovascular risk between patients with type 2 diabetes and those who had had a myocardial infarction; cross sectional and cohort studies. Br Med J. 2002;324:939–43.

    Article  Google Scholar 

  2. Roberto P, Giovanna L, Maura R, Francesca V, Simone V, Elena R, et al. Microalbuminuria, cardiovascular, and renal risk in primary hypertension. J Am Soc Nephrol. 2002;13S:169–72.

    Google Scholar 

  3. Rutter MK, McComb JM, Forster J, Brady S, Marshall SM. Increased left ventricular mass index and nocturnal systolic blood pressure in patients with Type 2 diabetes mellitus and microalbuminuria. Diabet Med. 2000;17:321–5.

    Article  PubMed  CAS  Google Scholar 

  4. Lengyel Z, Voros P, Toth LK, Nemeth C, Kammerer L, Mihaly M, et al. Urinary albumin excretion is correlated to fibrinogen levels and protein S activity in patients with type 1 diabetes mellitus without overt diabetic nephropathy. Wien Klin Wochenscher [abstract]. 2004;16(7–8):240–5.

    Article  Google Scholar 

  5. Song Ki-Ho, Ko Seung Hyun, Kim Hyung-Wook, Ahn Yu-Bae, Lee Jong-Min, Hyun shik Son, et al. Prospective study of lipoprotein(a) as a risk factor for deteriorating renal function in Type 2 diabetic patients with overt proteinuria. Diabetes Care. 2005;28(7):1718–23.

    Article  PubMed  CAS  Google Scholar 

  6. Fox CS, Coady S, Sorlie PD, D’Agostino RB Sr, Pencina MJ, Vasan RS, et al. Increasing cardiovascular disease burden due to diabetes mellitus: the framingham heart study. Circulation. 2007;115:1544–50.

    Article  PubMed  Google Scholar 

  7. Khan TM, Marwat MA, Khan P, Wazir F, Rehman A. Plasma fibrinogen levels in diabetics with complications- a prospective study. Gomal J Med Sci. 2005;3(2):48–50.

    Google Scholar 

  8. Siekmeier R, Scharnagl H, Kostner GM, Grammer T, Stojakovic T, Marz W. Lipoprotein (a)- structure, epidemiology, function and diagnostics of a cardiovascular risk marker. Open Clin Chem J. 2008;1:79–91.

    Article  CAS  Google Scholar 

  9. Salmasi Abdul-Majeed. The degree of albuminuria is related to left ventricular hypertrophy in hypertensive diabetics and is associated with abnormal left ventricular filling: a pilot study. Angiology [abstract]. 2003;54(6):671–8.

    Article  Google Scholar 

  10. Devereux RB, Roman MJ, Paranicas M, O’Grady MJ, Lee ET, Welty TK, et al. Impact of diabetes on cardiac structure and function: the strong heart study 1. Circulation. 2000;101(19):2271–6.

    Article  PubMed  CAS  Google Scholar 

  11. Heinrich J, Assmann G. Fibrinogen and cardiovascular risk. Eur J Cardiovasc Prev Rehabil [abstract]. 1995;2(3):206–15.

    Article  Google Scholar 

  12. Edem MS, Emeribe AO, Akpotuzor JO. Changes in heamorrheologic and fibrinolytic activities upon hypertension and diabetic chemotherapy in Calabar diabetic residents, Nigeria. Afr J Biol Res. 2010;4(2):28–32.

    Google Scholar 

  13. Festa AD, Agostino R Jr, Tracy RP, Haffner SM. The insulin resistance atherosclerosis study, elevated levels of acute protein and plasminogen activator inhibitor predict the development of type 2 diabetes. Diabetes. 2002;4:1131–7.

    Article  Google Scholar 

  14. Khare KC, Raman PG, Bhatnagar AD, Bhavsar R. Serum Lp(a) levels in patients of diabetes mellitus. Int J Diabetes Dev Ctries. 2000;20:79–84.

    Google Scholar 

  15. Angles-Cano E, de la Pena Diaz A, Loyau S. Inhibition of fibrinolysis by lipoprotein(a). Ann NY Acad Sci [abstract]. 2001;936:261–75.

    Article  CAS  Google Scholar 

  16. Meca T, Mlekusch W, Doweik L, Budinsky AC, Bischof M, Minar E, Schillinger M. Influence and interaction of diabetes and lipoprotein (a) serum levels on mortality of patients with peripheral artery disease. Eur J Clin Investig [abstract]. 2007;37(3):180–6.

    Article  Google Scholar 

  17. Karadi L, Romics L, Palos G, Doman J, Kaszas I, Haaz A, et al. Lp(a) lipoprotein concentration in serum of patients with heavy proteinuria of different origin. Clin Chem. 1989;35(10):2121–3.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Endocrinology, Dayanand Medical College and Hospital, Ludhiana, India

    Parminder Singh

  2. Department of Medicine, Dayanand Medical College and Hospital, Ludhiana, India

    Gaurav Singla

  3. Department of Biochemistry, Dayanand Medical College & Hospital, Ludhiana, 141 001, Punjab, India

    Satinder Kaur & Verma Indu

Authors
  1. Satinder Kaur
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Parminder Singh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Verma Indu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Gaurav Singla
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Satinder Kaur.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kaur, S., Singh, P., Indu, V. et al. Fibrinogen, Lp(a), Microalbuminuria and Left Ventricular Mass Index: Cardiovascular Disease Risk factors in Diabetes. Ind J Clin Biochem 27, 94–96 (2012). https://doi.org/10.1007/s12291-011-0184-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12291-011-0184-5

Keywords

Search

Navigation