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Evaluation of Oxidative Stress and Antioxidant Status in Pregnant Anemic Women

Indian Journal of Clinical Biochemistry volume 25, pages 411–418 (2010)Cite this article

Abstract

The present study was conducted to investigate the oxidant–antioxidant status in iron deficient pregnant anemic women. One hundred thirty pregnant women with iron deficiency anemia (IDA) were divided into three groups, namely mild (50), moderate (50) and severe (30) anemic along with pregnant healthy women as controls (50). The complete blood count, plasma lipid peroxidation products, enzymatic and non-enzymatic antioxidants were measured according to respective protocols. The levels of complete blood count, iron, ferritin along with antioxidant enzymes namely catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and reduced glutathione were significantly reduced in all IDA groups. However, the level of oxidized glutathione, lipid peroxides, protein carbonyls, conjugated dienes were found significantly increased in all anemic patients. Antioxidant vitamins, namely C, E and A were also found significantly decreased in IDA patients. On the basis of our results, it may be concluded that IDA tends to increase the pro-oxidant components, which may result in various complications including peroxidation of vital body molecules resulting in increased risk for pregnant women as well as fetus.

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Acknowledgments

Authors acknowledge with thanks the help and guidance of Prof. R. K. Singh (ex-HOD, Biochemistry, CSM Medical University, Lucknow). Authors would like to acknowledge the financial assistance in the form of senior research fellowship given by Council of Science & Technology, U.P.

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Affiliations

  1. Department of Biochemistry, C.S.M. Medical University, Lucknow, India

    Amit Kumar Mani Tiwari & Abbas Ali Mahdi

  2. Department of Obstetrics and Gynecology, Era’s Lucknow Medical College and Hospital, Lucknow, India

    Fatima Zahra

  3. Department of Biochemistry, Bundelkhand University, Jhansi, India

    Sudarshna Chandyan

  4. Department of Community Medicine, C.S.M. Medical University, Lucknow, India

    Vinod Kumar Srivastava

  5. Biometry Division, Central Drug Research Institute, Lucknow, India

    Mahendra P. Singh Negi

  6. Medical Elementology and Free Radical Biology Lab, Department of Biochemistry, King George’s Medical University, Lucknow, 226003, India

    Abbas Ali Mahdi

Authors
  1. Amit Kumar Mani Tiwari
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  2. Abbas Ali Mahdi
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  3. Fatima Zahra
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  4. Sudarshna Chandyan
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  5. Vinod Kumar Srivastava
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  6. Mahendra P. Singh Negi
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Correspondence to Abbas Ali Mahdi.

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Tiwari, A.K.M., Mahdi, A.A., Zahra, F. et al. Evaluation of Oxidative Stress and Antioxidant Status in Pregnant Anemic Women. Ind J Clin Biochem 25, 411–418 (2010). https://doi.org/10.1007/s12291-010-0067-1

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  • DOI: https://doi.org/10.1007/s12291-010-0067-1

Keywords

  • Iron deficiency anemia
  • Oxidants
  • Antioxidants
  • Pregnancy