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Indian Journal of Clinical Biochemistry

, Volume 25, Issue 4, pp 393–397 | Cite as

Effect of Turmeric and its Active Principle Curcumin on T3-Induced Oxidative Stress and Hyperplasia in Rat Kidney: A Comparison

  • Luna SamantaEmail author
  • Jogamaya Panigrahi
  • Shravani Bhanja
  • Gagan B. N. Chainy
Original Article

Abstract

The present study was designed to compare the potential of turmeric and its active principle curcumin on T3-induced oxidative stress and hyperplasia. Adult male Wistar strain rats were rendered hyperthyroid by T3 treatment (10 μg · 100 g−1 · day−1 intraperitoneal for 15 days in 0.1 mM NaOH) to induce renal hyperplasia. Another two groups were treated similarly with T3 along with either turmeric or curcumin (30 mg kg−1 body weight day−1 orally for 15 days). The results indicate that T3 induces both hypertrophy and hyperplasia in rat kidney as evidenced by increase in cell number per unit area, increased protein content, tubular dilation and interstitial edema. These changes were accompanied by increased mitochondrial lipid peroxidation and superoxide dismutase activity without any change in catalase activity and glutathione content suggesting an oxidative predominance. Both turmeric and curcumin were able to restore the level of mitochondrial lipid peroxidation and superoxide dismutase activity in the present dose schedule. T3-induced histo-pathological changes were restored with turmeric treatment whereas curcumin administration caused hypoplasia. This may be due to lower concentration of curcumin in the whole turmeric. Thus it is hypothesized that regulation of cell cycle in rat kidney by T3 is via reactive oxygen species and curcumin reveres the changes by scavenging them. Although the response trends are comparable for both turmeric and curcumin, the magnitude of alteration is more in the later. Turmeric in the current dose schedule is a safer bet than curcumin in normalizing the T3-induced hyperplasia may be due to the lower concentration of the active principle in the whole spice.

Keywords

Oxidative stress Kidney Curcumin Turmeric Hyperplasia Thyroid 

Notes

Acknowledgments

Financial assistance to the Departments from the Department of Biotechnology and University Grants Commission, Government of India is gratefully acknowledged.

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Copyright information

© Association of Clinical Biochemists of India 2010

Authors and Affiliations

  • Luna Samanta
    • 1
    • 2
    Email author
  • Jogamaya Panigrahi
    • 2
  • Shravani Bhanja
    • 2
  • Gagan B. N. Chainy
    • 2
    • 3
  1. 1.Department of ZoologyRavenshaw UniversityCuttackIndia
  2. 2.Departments of Zoology and BiotechnologyUtkal UniversityBhubaneswarIndia
  3. 3.Imgenex India Pvt. Ltd., E-5, InfocityBhubaneswarIndia

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