Skip to main content
SpringerLink
Log in

Effect of Curcuma longa freeze dried rhizome powder with milk in STZ induced diabetic rats

  • Original Article
  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

This study deals with the effects of freeze dried rhizome powder of Curcuma longa (C. longa) dissolved in milk on normal as well as diabetic models. Diabetes of type II and type I was within 3 days of a single administration of doses of 45 and 65 mg kg−1 of streptozotocin respectively. Various parameters such as blood glucose levels, triglycerides, total cholesterol, high density lipoprotein, very low density lipoprotein, low density lipoprotein, serum glutamic oxaloacetic transaminase, serum glutamic pyruvate transaminase, alkaline phosphatase, creatinine, hemoglobin, urine protein and urine sugar in addition to body weight were taken in to consideration and were analyzed after administration of variable doses of rhizome powder. The dose of 200 mg kg−1 was identified as the most effective dose as it increased HDL, Hb and bw (P<0.05) with significant decrease in the levels of blood glucose, lipid profile and hepatoprotective enzymes (P<0.001).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Marles RJ, Fransworth NR. Antidiabetic plants and their active constituents. Phytomedicine 1995; 2: 137–189.

    Google Scholar 

  2. Irrova, MD, Paya M, Villar A. A review of natural products and plants as potential antidiabetic drugs. J Ethnopharmacol 1989; 27: 243–275.

    Article  Google Scholar 

  3. Rai PK, Jiaswal D, Diwakar S, Watal G. Antihyperglycemic Profile of Trichosanthes dioica Seeds in Experimental Models. Pharm Biol 2008; 46(5): 1–6.

    Article  Google Scholar 

  4. Singh SK, Kesari AN, Gupta RK, Jaiswal D, Watal G. Assessment of antidiabetic potential of Cynodon dactylon extract in streptozotocin diabetic rats. J Ethnopharmacol 2007; 114: 174–179.

    Article  PubMed  Google Scholar 

  5. Ammon HPT, Wahal MA. Pharmacology of Curcuma longa. Planta Medica. 1991; 57: 1–7.

    Article  CAS  PubMed  Google Scholar 

  6. Eigner D, Scholz D. Ferula asa-foetida and Curcuma longa in traditional medicine treatment and diet in Nepal. J Ethnopharmacol 1999; 67: 1–6.

    Article  CAS  PubMed  Google Scholar 

  7. Eshrat H, Hussain MALI. Hypoglycemic, hypolipidemic and antioxidant properties of combination of Curcumin from Curcuma longa, Linn and partially purified product from Abroma augusta, Linn. In Streptozotocin induced diabetes. Ind J Clin Biochem 2002; 17: 33–43.

    Article  Google Scholar 

  8. Davidson MB. Diabtes Mellitus, Diagnosis and Treatment. Wiley, New York 1981: pp. 27–157.

    Google Scholar 

  9. Rai PK, Rai NK, Rai AK, Watal G. Role of LIBS in elemental analysis of P. guajava responsible for glycemic potential. Inst Sc Tech 2007;35(5): 507–522.

    Article  CAS  Google Scholar 

  10. Maghrani M, Zeggwagh NA, Lemhadri A, Amraoui M, Michel JB, Eddouks M. Study of the hypoglycaemic activity of Fraxinus excelsior and Silybum marianum in an animal model of type 1 diabetes mellitus. J Ethnopharmacol 2004; 91: 309–316.

    Article  CAS  PubMed  Google Scholar 

  11. Burcelin R, Rodriguez-gabin AG, Charron MJ, Almazan G, Larocca JN. Long-lasting antidiabetic effect of a dipeptidyl peptidase IV-resistant analog of glucagon-like peptide-1. Metabolism 1999; 48: 252–258.

    Article  CAS  PubMed  Google Scholar 

  12. Brahm D, Trinder P. Estimation of glucose by glucose oxidase method. Analyst 1972; 97: 142–145.

    Article  Google Scholar 

  13. Alian CC, Poon LS, Chan CS, Richmond WFU. Enzymatic determination of total cholesterols. Clin Chem 1974; 20: 470–475.

    Google Scholar 

  14. Buccolo G, David M. Quantitative determination of Serum Triglycerides by use of enzyme. Clin Chem 1973; 19: 476–482.

    Google Scholar 

  15. Henry RJ, Canon DC, Winkelman JW. Clinical Chemistry Principals and Techniques, 2nd edn, 1974. New York, Harper and Row.

    Google Scholar 

  16. Hansman TU. Expert Panel of the IFCC on enzymes. Clin Chem Acta Clin Biochem 1976; 70: 19.

    Google Scholar 

  17. Stricklad RD, Freeman ML, Gurule FF. Copper binding by proteins in Alkaline solution. Analytical Chem 1961; 33: 125–128.

    Article  Google Scholar 

  18. Gambino SR, Meites S. Standard methods of Clinical Chemistry, New York Academic Press 1965; 5, pp. 55.

    CAS  Google Scholar 

  19. Nonfon M, Lieb F, Moeschler H, Wendish D. Four anonins from Annona squamosa. Phytochem 1990; 29: 1951–1954.

    Article  CAS  Google Scholar 

  20. Friedwald WT, Ley RI, Fradrickson DS. Estimation of low-density lipoprotein cholesterol in plasma without the use of preparative ultracentrifuge. Clin Chem 1972; 18: 499–502.

    Google Scholar 

  21. Tsiani E, Bogdanovic E, Sorisky A, Nagy L, Fantus IG. Tyrosine phosphatase inhibitors, vanadate and pervanadate, stimulate glucose transport and GLUT translocation in muscle cells by a mechanism independent of phosphatidylinositol 3-kinase and protein kinase C. Diabetes 1998; 47: 1676–1686.

    Article  CAS  PubMed  Google Scholar 

  22. Eyrich M, Croner T, Leiler C, Lang P, Bader P, Klingebiel T, Niethammer D, Paul G. Distinct contributions of CD4 + and CD8 + naive and memory T-cell subsets to overall T-cell-receptor repertoire complexity following transplantation of T-cell-depleted CD34-selected hematopoietic progenitor cells from unrelated donors. Blood 2002; 100: 1915–1918.

    Article  CAS  PubMed  Google Scholar 

  23. Horwitz MS, Bradley LM, Harbertson JK, Jael NS. Diabetes induced by Coxsackie virus: Initiation by bystander damage and not molecular mimicry. Nature Medicine 1998; 4: 781–785.

    Article  CAS  PubMed  Google Scholar 

  24. Blondel O, Bailbe D, Portha B. In vivo insulin resistance in streptozotocin-diabetic rats -evidence for reversal following oral vanadate treatment. Diabetologia 1989;32: 185–190.

    Article  CAS  PubMed  Google Scholar 

  25. Hofteizer V. Comparison of streptozotocin-induced diabetes in the rat inducing volumetric quantitation of the pancreatic islets. Diabetologia 1973; 9: 178–184.

    Article  Google Scholar 

  26. Goodman LS, Gilman A. The Pharmacological Basis of Therapeutics, 7th ed., Macmillan, New York, 1985; pp. 1490–1510.

    Google Scholar 

  27. Rhoads GG, Gulbrandse CL, KAGEN. A Serum lipoprotein and coronary artery disease in a population study of Hawaiian Japanese men. N Eng J Med 1976; 294: 293–298.

    Article  CAS  Google Scholar 

  28. Zhang N, Ping QN, Huang G, Wen FXU. Investigation of lectinmodified insulin liposomes as carriers for oral administration. Int J Pharmaceuticals 2006; 194: 147–259.

    Google Scholar 

  29. Batran AS, Omer ME, Salam A, Salwa M, Nofal RB. Effect of rosiglytazone and Nateglinide on serum glucose and lipoid profile alone or in combination with the biguanide metformin in diabetic rats. Pharmacol Res 2006; 53: 69–74.

    Article  PubMed  CAS  Google Scholar 

  30. Olivarius DN, Andresen H, Anne EV, Holstein-rathlou NH, Jorgensen GM., Mogensen CE. Urinary creatinine concentration is inversely related to glycemic control and the presence of some diabetic complications in patents with newly diagnosed Type 2 diabetes. J Diabetes and its Complications 2006; 20: 45–50.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Alternative Therapeutics Unit, Drug Discovery & Development Division, Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad, 211 002, India

    P. K. Rai, D. Jaiswal, S. Mehta & Geeta Watal

  2. Department of Biochemistry, University of Allahabad, Allahabad, 211 002, India

    D. K. Rai & B. Sharma

Authors
  1. P. K. Rai
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Jaiswal
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Mehta
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. D. K. Rai
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. B. Sharma
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Geeta Watal
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Geeta Watal.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rai, P.K., Jaiswal, D., Mehta, S. et al. Effect of Curcuma longa freeze dried rhizome powder with milk in STZ induced diabetic rats. Indian J Clin Biochem 25, 175–181 (2010). https://doi.org/10.1007/s12291-010-0032-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12291-010-0032-z

Key Words

Search

Navigation