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Circulating thrombotic and haemostatic components in patients with coronary artery disease

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Abstract

The study aimed to analyze the circulating levels of thrombotic and haemostatic components; tissue factor, tissue factor pathway inhibitor, tissue plasminogen activator and plasminogen activator inhibitor-1 in patients with acute myocardial infarction at presentation (Group 1, n=49), unstable angina and Non-ST elevated MI after treatment (Group 2, n=22), stable angina (Group 3, n=18) and healthy individuals (Group 4, n=31). Significant finding was increase in tissue factor not only in Group 1 (2.0 fold, P=0.001), Group 2 (2.2 fold, P=0.015) but also in Group 3 (1.8 fold, P=0.018) as compared to controls. In Group 1 Plasminogen activator inhibitor-1 increased significantly (35.8%, P=0.02). Tissue factor pathway inhibitor and tissue plasminogen activator demonstrated increase in Group 1 of age<40 years while insignificant changes in elder patients. Increased thrombotic and decreased fibrinolytic conditions in acute myocardial infarction patients were observed. Increase TF in stable angina demonstrates procoagulant status in these patients as well.

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Authors and Affiliations

  1. H. N. Medical Research Society, Sir H. N. Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai, 400 004, India

    Kavita K. Shalia, R. A. Mokal, S. M. Mithbawkar, K. V. Kudalkar, A. Abraham & P. K. Thakur

  2. Sir H. N. Hospital and Research Centre, Raja Rammohan Roy Road, Mumbai, 400 004, India

    V. K. Shah, M. R. Mashru, S. L. Soneji & J. B. Vasvani

  3. Rajawadi Municipal Hospital, Ghatkopar (East), Mumbai, India

    S. S. Payannavar & A. P. Walvalkar

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  1. Kavita K. Shalia
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  2. V. K. Shah
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Correspondence to Kavita K. Shalia.

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Shalia, K.K., Shah, V.K., Mashru, M.R. et al. Circulating thrombotic and haemostatic components in patients with coronary artery disease. Indian J Clin Biochem 25, 20–28 (2010). https://doi.org/10.1007/s12291-010-0005-2

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