Abstract
The aim of the study was to ascertain the role of ethanolic extract of Cynodon dactylon against hepatic complications in streptozotocin (STZ) induced type 2 diabetic models. Effect of the pre identified most effective dose of 500 mg/kg body weight was studied on hepatic injury caused by chemically induced diabetes by 55 mg/kg body weight i.p. injection of STZ in male Wistar rats. The dose of 500mg/kg body weight given once daily for 14 days reduced the levels of serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, alkaline phosphatase, creatinine and urine sugar significantly (P<0.05) with increase in total protein, haemoglobin and body weight was increased. High LD50 validates its high margin of safety.
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Singh, S.K., Rai, P.K., Mehta, S. et al. Curative effect of Cynodon dactylon against STZ induced hepatic injury in diabetic rats. Indian J Clin Biochem 24, 410–413 (2009). https://doi.org/10.1007/s12291-009-0073-3
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DOI: https://doi.org/10.1007/s12291-009-0073-3