Skip to main content

Advertisement

Log in

Serum anti — TPO levels in benign and malignant breast tumors

  • Original Articles
  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

Breast cancer is a hormone dependent neoplasm. Conflicting results regarding the clinical correlation between breast cancer and thyroid diseases have been reported. The objective of this study was to determine the association of anti — TPO levels in patients having complaints of a lump in breast. Serum samples and Fine needle aspiration cytology (FNAC) samples were collected from 31 female patients with a lump in breast between the age group of 20–75 years. 31 age matched normal healthy controls were also examined for the same parameters. Serum samples were analyzed for its anti — TPO levels. FNAC reports confirmed patients as having duct cell carcinoma. They had raised serum anti — TPO levels compared to controls. FNAC results of others (n=26) were reported as fibroadenoma whose anti — TPO levels were less than the controls.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Mittra I, Perrin J, Kumaoka S. Thyroid and other autoantibodies in British and Japenese women: an epidemiological study of breast carcinoma. Br Med J 1976; 1: 257–259.

    Article  PubMed  CAS  Google Scholar 

  2. Elsei R, Vivaldi A, Pacini F. Biology and clinical application of the NIS gene. Tumori 2003; 89(5): 523–528.

    Google Scholar 

  3. Spitzweg C. The sodium — iodide symporter. Pathophysiologic, diagnostic and therapeutic significance. Internist 2003; 44: 396–402.

    PubMed  CAS  Google Scholar 

  4. Smyth PP, Smith DF, Mc Dermott EWM, Murray MJ, Geraghty JG, O’ Higgins NJ. A direct relationship between thyroid enlargement and breast carcinoma. J Clin Endocrinol Metab 1996; 81: 937–941.

    Article  PubMed  CAS  Google Scholar 

  5. Dulger H, Alici S, Algun E, Etlik O, Sayarlioglu M, Dogan E, et al. Antithyroid antibody levels with breast cancer. Eur J Gen Med 2004; 1(2): 11–14.

    Google Scholar 

  6. Smyth PPA. Autoimmune thyroid disease and breast cancer: a chance association. J Endocrinol Invest 2000; 23: 42–43.

    PubMed  CAS  Google Scholar 

  7. Smyth PP, Shering SG, Kilbane MT, Murray MJ, McDermott EW, Smith DF, et al. Serum thyroid peroxidase autoantibodies, thyroid volume and outcome in breast carcinoma. J Clin Endocrinol Metab 1998; 83: 2711–276.

    Article  PubMed  CAS  Google Scholar 

  8. Turken O, Narin Y, Demirbas S, Onde ME, Sayan O, Kandemir EG, Yaylacy M, Ozturk A. Breast cancer in association with thyroid disorders. Breast Cancer Res 2003; 5: 110–113.

    Article  Google Scholar 

  9. Teng W, Shan Z, Teng X, Guan H, Li Y, Teng D, et al. Effect of iodine intake on thyroid diseases in China. N Eng J Med 2006; 354: 2783–2793.

    Article  CAS  Google Scholar 

  10. Giani C, Fierabracci P, Bonacci R. Relationship between breast cancer and thyroid disease. J Clin Endocrinol Metab 1996; 81: 990–994.

    Article  PubMed  CAS  Google Scholar 

  11. Davies TF. The thyrotrophin receptors spread themselves around. J Clin Endocrinol Metabol 1994; 79: 1232–1238.

    Article  CAS  Google Scholar 

  12. Aksoy H, Erkoc R, Sayarlioglu M, Dilek I, Ilhan M, Alici S, et al. Goiter survey in Van Province and thyroid functions in people older than 60. XXI National Endocrinology and Metabolism Disease congress. 29th September — 3rd October 1998, Istanbul, Abstract book. P: 13.

  13. Ron E, Curtis R, Hoffman DA, Flannery JT. Multiple primary breast and thyroid cancer. Br J Cancer 1984; 49: 87–90.

    PubMed  CAS  Google Scholar 

  14. Mohanty S, Lal WA, Reddy GC, Kusumanjali G, Kanagasabapathy AK, Rao P. Diagnostic strategies for subclinical Hypothyroidism. Ind J Clin Biochem 2008; 23(3): 279–282.

    Article  CAS  Google Scholar 

  15. Funahashi H. Wakame seaweed suppresses the proliferation of 7,12-dimethylbenz(a)-anthracene-induced mammary tumors in rats. Jpn J Cancer Res 1999; 90: 992–997.

    Google Scholar 

  16. Funahashi H, Imai T, Mase T, Sekiya M, Yokoi K, Hayashi H, et al. Seaweed prevents breast cancer. Jpn J Cancer Res 2001; 92: 483–487.

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sabitha.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sabitha, Suneetha, Mohanty, S. et al. Serum anti — TPO levels in benign and malignant breast tumors. Indian J Clin Biochem 24, 266–268 (2009). https://doi.org/10.1007/s12291-009-0050-x

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12291-009-0050-x

Key Words

Navigation