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Preliminary studies on the hypoglycemic effect of Peganum harmala L. Seeds ethanol extract on normal and streptozotocin induced diabetic rats

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Abstract

Peganum harmala L. (Zygophyllaceae) is a traditional medicine used for the treatment of variety of human ailments, including antidepression, hallucination, antileishmaniasis etc. We report for first time the hypoglycemic activity of the ethanolic extract of this plant at two dose levels of 150 and 250mg/kg bw in sucrose challenged normal as well as in rats with streptozotocin induced diabetes. The oral administration of ethanolic extract causes maximum fall of blood glucose level to 22.9% (p<0.05) and 29.4% (p<0.01) respectively with the two doses in normal and 30.3% (p<0.01) and 48.4% (p<0.001) in diabetic rats. The standard drug metformin treated group showed 28.0% (p<0.01) and 45.5% (p<0.001) respectively in normal and diabetic rats. The above results show that the ethanolic extract of P. harmala is as effective as metformin in reducing the blood glucose levels of normoglycemic and streptozotocin-induced diabetic rats.

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References

  1. Boyle JP, Honeycutt AA, Narayan KM, Hoerger TJ, Geiss LS, Chen H, et al. Projection of Diabetes Burden through 2050. Diabetes Care 2001; 24:1936–1940.

    Article  PubMed  CAS  Google Scholar 

  2. Grover JK, Yadav S, Vats V. Medicinal plants of India with anti-diabetic potential. J Ethnopharmacol 2002; 81:81–100.

    Article  PubMed  CAS  Google Scholar 

  3. Ivorra MD, Paya M, Villar A. A review of natural products and plants as potential antidiabetic drugs. J Ethnopharmacol 1989; 27:243–275.

    Article  PubMed  CAS  Google Scholar 

  4. Shukla R, Sharma SB, Puri D, Prabhu KM, Murthy PS. Medicinal plants for tretment of diabetes mellitus. Ind J Clin Biochem 2000;15(Suppl):169–177.

    Article  Google Scholar 

  5. Chopra IC, Jamwal KS, Pillay PP, Santhakumari TN. Pharmacological action of Lochnera rosea linn (Rattanjot). Ind J Med Res 1957; 45:567–570.

    CAS  Google Scholar 

  6. Farzin D, Mansouri N. Antidepressant-like effect of harmane and other beta-carbolines in the mouse forced swim test. Eur J Neuropsychopharmacol 2006;16:324–328.

    Article  CAS  Google Scholar 

  7. Glennon RA, Dukat M, Grella B, Hong SO, Costantino L, Teitler M, et al. Binding of beta-carbolines and related agents at serotonin (5-HT (2) and 5-HT (1A)), dopamine (D (2)) and benzodiazepine receptors. Drug Alcohol Dependent 2000; 60:121–132.

    Article  CAS  Google Scholar 

  8. Giorgio A, Ferraioli G, Tarantino L, de Stefano G, Scala V, Scarano F, et al. Contrast-enhanced sonographic appearance of hepatocellular carcinoma in patients with cirrhosis: comparison with contrast-enhanced helical CT appearance. Am J Roentgenol 2004; 183:1319–1326.

    Google Scholar 

  9. Shukla P, Singh AB, Srivastava AK, Pratap R. Chalcone based aryloxypropanolamines as potential antihyperglycemic agents. Bioorganic & Medicinal Chemistry Letters 2007; 17:799–802.

    Article  CAS  Google Scholar 

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Correspondence to Arvind K. Srivastava.

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Singh, A.B., Chaturvedi, J.P., Narender, T. et al. Preliminary studies on the hypoglycemic effect of Peganum harmala L. Seeds ethanol extract on normal and streptozotocin induced diabetic rats. Indian J Clin Biochem 23, 391–393 (2008). https://doi.org/10.1007/s12291-008-0086-3

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