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Effect of water extract of Trichosanthes dioica fruits in streptozotocin induced diabetic rats

Indian Journal of Clinical Biochemistry volume 23, pages 387–390 (2008)Cite this article

Abstract

In rats with streptozotocin induced severe diabetes mellitus, aqueous extract of Trichosanthes dioica fruits at a dose of 1000mg/kg body weight daily once for 28 days reduced the levels of fasting blood glucose, postprandial glucose, asparate amino transferase, alanine amino transferase, alkaline phosphatase, creatinine, urine sugar and urine protein where as total protein and body weight was increased. No toxic effect was observed during LD50. Our study suggests that further detailed toxicity studies and mechanism of action of T. dioica would be useful for undertaking human trials.

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References

  1. Rai PK, Rai NK, Rai AK, Watal G. Role of LIBS in elemental analysis of P. guajava responsible for glycemic potential. Inst Sc Tech 2007;35(5): 507–522.

    Article  CAS  Google Scholar 

  2. Finn RD, Jones CG. Avenues of discovery in bioprospecting. Nature 1998; 393: 617.

    Google Scholar 

  3. Mukherjee PK, Maiti K, Mukherjee K, Houghton JP. Leads from Indian medicinal plants with hypoglycemic potentials. J Ethnopharmacol 2006; 106: 1–28.

    Article  PubMed  CAS  Google Scholar 

  4. Mukherjee PK, Venkatesh M, Kumar V. An overview on the development in regulation and control of medicinal and aromatic plants in the indian system of medicine. Bol Latinoam Caribe Plant Med Aromaticas 2007; 6 (4): 129–136.

    Google Scholar 

  5. Chakravarthy HM. Fascicles of floraofIndia-11 Cucurbitacae. Botanical survey of India 1982; 136 pp.

  6. Sharma G, Sarkar A, Pachori SB, Pant MC. Biochemical evaluation of raw Trichosanthes dioica whole fruit and pulp in normal and mild- diabetic human volunteers in relation to lipid profile. Ind Drug 1989; 27: 24–28.

    Google Scholar 

  7. Singh K. Pointed ground. Indian Horticul 1989; 33 & 34: 33–37.

    Google Scholar 

  8. Sharma G, Pant MC. Effect of feeding Trichosanthes dioica (Parval) whole fruits on blood glucose, serum triglycerides, phospholipid, cholesterol and high density lipoprotein-cholesterol levels in the normal albino rabbits. Curr Sci 1988; 57: 1085–1087.

    Google Scholar 

  9. Mukharjee SK. Scope and use of indigenous herbal drugs in’ Madhumeha’ An Indian scenario. International seminar on free radicals, mediated diseases. Indian scenario (Abstract-11) 1996; 2–4 September, Varansi, India.

  10. Rai PK, Jaiswal D, Diwakar S, Watal G. Antihyperglycemic Profile of Trichosanthes dioica Seeds in Experimental Models. Pharm Biol 2008; 46(5): 1–6.

    Article  Google Scholar 

  11. Rai PK, Jaiswal D, Singh R, Watal G. Glycemic property of Trichosanthes dioica leaves. Pharm Biol 2008 (In press).

  12. Brahm D, Trinder P. Estimation of glucose by glucose oxidase method. Analyst 1972; 97, 142–145.

    Article  Google Scholar 

  13. Henry RJ, Canon DC, Winkelman JW. Clinical Chemistry Principals and Techniques, 2nd edn, New York, Harper and Row 1974.

    Google Scholar 

  14. Expert Panel on Enzymes: Committee on standards of IFCC provisional recommendations on IFCC methods for measurement of catalytic concentration of enzymes. Part 2. IFCC method for aspartate aminotransferase. Clin Chim Acta 1976; 70: F19–F42.

    Article  Google Scholar 

  15. Gambino SR. In Meites S (ed): Standard methods of Clinical Chemistry, New York Academic Press 1965; 5: 55 pp.

    Google Scholar 

  16. Gupta RK, Kesari AN, Watal G, Murthy PS, Chandra RC, Tandon V. Nutritional and Hypoglycemic Effect of Fruit Pulp of Annona squamosa in Normal Healthy and Alloxan-Induced Diabetic Rabbits. Annals of Nutrition of Metabolism 2005; 49:407–413.

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Alternative Therapeutics Unit, Drug Discovery & Development Division,. Medicinal Research Lab, Department of Chemistry, University of Allahabad, Allahabad, 211002, India

    Prashant Kumar Rai, Dolly Jaiswal, Devendra K. Rai, Bechan Sharma & Geeta Watal

  2. Biochemistry, University of Allahabad, Allahabad, 211002, India

    Devendra K. Rai & Bechan Sharma

Authors
  1. Prashant Kumar Rai
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  2. Dolly Jaiswal
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  3. Devendra K. Rai
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  4. Bechan Sharma
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  5. Geeta Watal
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Correspondence to Geeta Watal.

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Rai, P.K., Jaiswal, D., Rai, D.K. et al. Effect of water extract of Trichosanthes dioica fruits in streptozotocin induced diabetic rats. Indian J Clin Biochem 23, 387–390 (2008). https://doi.org/10.1007/s12291-008-0085-4

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  • DOI: https://doi.org/10.1007/s12291-008-0085-4

Key words

  • Antidiabetic effect
  • Hepatoprotective
  • Trichosanthes dioica