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Alpha-1-Antitrypsin Experience for Steroid-Resistant Acute Graft-Versus-Host Disease


Steroid-refractory acute graft-versus-host disease (SR-aGVHD) treatment has a low response rate and a high risk of infection in allogeneic hematopoietic stem cell transplantation. The standard approach to be applied in this situation is uncertain. This study aims to evaluate the effectiveness and safety of alpha-1-antitrypsin (AAT). In the study, the results of five SR-aGVHD patients received AAT evaluated. Complete response was seen 2 of four patients with gastrointestinal (GI) aGVHD, partial response in one GI and one liver aGVHD. The overall response rate was 80%. AAT is an effective and safe treatment option in SR-aGVHD.

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Authors and Affiliations



Surgical and Medical Practices: D.K, S.CB, SK.T, M.KY, M.O, G.CS, E.K, P.T, O.A, T.D, O.I, M.B, G.G. Concept: D.K, G.CS, M.KY, S.CB, M.O. Design: D.K, G.CS, M.KY, Data Collection or Processing: D.K, G.CS, E.K. Analysis or Interpretation: D.K, G.CS. Literature Search: M.O, D.K, SK.T, G.CS. Writing: D.K, G.CS.

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Correspondence to Derya Koyun.

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Koyun, D., Seval, G.C., Kırcalı, E. et al. Alpha-1-Antitrypsin Experience for Steroid-Resistant Acute Graft-Versus-Host Disease. Indian J Hematol Blood Transfus 38, 601–605 (2022).

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  • AAT
  • SR-aGVHH