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Blocking Phenomenon Occurs in a Neonate with a Positive Direct Antiglobulin Test Due to Maternal Anti-D, Anti-C Antibodies: Resolved by Chloroquine Diphosphate Treatment

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References

  1. Wiener AS (1944) A new test (blocking test) for Rh sensitization. In: Proceedings of the society for experimental biology and medicine, vol 56, New York, pp 173–176

  2. Lee E (2013) Blocked D phenomenon. Blood Transfus 11:10–11

    PubMed  PubMed Central  Google Scholar 

  3. Edwards JM, Moulds JJ, Judd WJ (1982) Chloroquine dissociation of antigen-antibody complexes. A new technique for typing red blood cells with a positive direct antiglobulin test. Transfusion 22:59–61

    Article  CAS  Google Scholar 

  4. Fung MK, Grossman BJ, Hillyer CD, Westhoff CM (2014) Methods section 2: red cell typing. In: American Association of Blood Banks edition. Technical manual, 18th edn: AABB, Bethesda

  5. Shirey RS, Mirabella DC, Lumadue JA, Ness PM (1997) Differentiation of anti-D, -C, and -G: clinical relevance in alloimmunized pregnancies. Transfusion 37:493–496

    Article  CAS  Google Scholar 

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The authors declared having no competing financial interest relevant to this article.

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AN performed the performed serologic testing and wrote drafts under supervision of PB. SSD analyzed all data and wrote the manuscript. All authors reviewed and edited the manuscript.

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Correspondence to Suvro Sankha Datta.

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Naik, A., Bhattacharya, P. & Datta, S.S. Blocking Phenomenon Occurs in a Neonate with a Positive Direct Antiglobulin Test Due to Maternal Anti-D, Anti-C Antibodies: Resolved by Chloroquine Diphosphate Treatment. Indian J Hematol Blood Transfus 36, 403–405 (2020). https://doi.org/10.1007/s12288-019-01190-x

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  • DOI: https://doi.org/10.1007/s12288-019-01190-x

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