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Is Cd11c and Fmc7 Negativity in Chronic Lymphocytic Leukemia Poor Prognostic?

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Chronic lymphocytic leukemia (CLL) is a common hematological malignancy. This study is aimed to investigate the prognostic effect of clinic, laboratory and flow cytometric analysis in CLL patients. Newly diagnosed 55 CLL cases were divided into two groups, as stable disease (Group 1) and progressive disease (Group 2). Group 1 included those who did not require any treatment since diagnosis and those who did not progress after receiving the first step anti CLL treatment. Group 2 included the patients who received ≥ 2 steps treatment. The relation between the two groups was analyzed statistically in terms of clinical, laboratory and flow cytometric findings. Twenty patients (36.3%) required treatment at the time of diagnosis, four patients (3.8%) received first-line treatment during follow-up and 31 (56.3%) patients were followed without any treatment. Thirteen patients required second step treatment after a median of 26.3 months. The risk of progression was found to be increased 5-fold (p = 0.015) in the CD38 positive patient group, 4.2-fold (p = 0.0147) in the FMC7 negative patient group and 2.8-fold in the CD11c negative patient group. FMC 7 negativity decreased total survival 5.9-fold (p = 0.051). Unlike similar publications, we found that patients with CD11c or FMC7 negativity were in a higher need for ≥ 2 step treatment. This suggests that CD11c or FMC7 negativity may be used as a poor prognostic marker in CLL.

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The authors declared that this study has received no financial support.

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Authors and Affiliations

  1. Department of Hematology, Yildirim Beyazit University, Bilkent Yolu 3. Km, Çankaya, 06010, Ankara, Turkey

    Aysun Şentürk Yikilmaz, Şule Mine Bakanay, Zeynep Büşra Zengin & İmdat Dilek

  2. Department of Hematology, Ataturk Training and Research Hospital, Ankara, Turkey

    Sema Akinci

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  1. Aysun Şentürk Yikilmaz
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  2. Sema Akinci
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Correspondence to Aysun Şentürk Yikilmaz.

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Şentürk Yikilmaz, A., Akinci, S., Bakanay, Ş.M. et al. Is Cd11c and Fmc7 Negativity in Chronic Lymphocytic Leukemia Poor Prognostic?. Indian J Hematol Blood Transfus 36, 84–90 (2020). https://doi.org/10.1007/s12288-019-01169-8

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  • DOI: https://doi.org/10.1007/s12288-019-01169-8

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