Skip to main content
Log in

Spectrum of Hemoglobinopathies: A New Revelation in a Tertiary Care Hospital of Odisha

  • Short Communication
  • Published:
Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

The prevalence of different types of hemoglobinopathies and its spectrum in Odisha state is believed to be high, but its exact prevalence is not known due to lack of large population based study. The present study was undertaken to know the magnitude and spectrum of hemoglobinopathies among the patients attending tertiary care centre for evaluation of anemia. All the patients of various age group without any history of blood transfusion preceding 3 months of period attending the Clinical Hematology Department of SCB Medical College, Cuttack for evaluation of anemia were included in this 10 year prospective study. Detail history, clinical examination followed by blood sample examination including by HPLC/CzE were done in all cases. Other investigations were done as per need of evaluation of anemia. Out of 21,371 patients with anemia, hemoglobinopathies was detected in 10,745 (50.2%) cases. The profile of hemoglobinopathy was as follows: HbS gene in 52.48% cases, betathalassemia in 54.06% and HbE hemoglobinopathies in 9.19% cases. Hemoglobinopathy was detected in very high percentage (50.2%) of cases in our centre. Various types of β-thalassemia and sickle cell hemoglobinopathies were two major types (54.06% and 52.48% respectively). This needs to be confirmed by large population based study.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Parikh UR, Goshwami HM, Mehta RC, Patel PS, Gosai RN (2014) Incidence of hemoglobinopathies in women attending antenatal clinics in their first trimester. J Med Sci 3(1):63–67

    Google Scholar 

  2. De Gruchy GC (1989) Disorders of hemoglobin structure and synthesis. In: Firkin FC, Chesterman CN, Penington DG, Rush BM (eds) De Gruchy’s clinical haematology in medical practice, 5th edn. Blckwell Science Ltd., Edinburgh, pp 137–165

    Google Scholar 

  3. Madan N, Sharma S, Sood SK, Colah R, Bhatia HM (2010) Frequency of β-thalassemia trait and other hemoglobinopathies in northern and western India. Indian J Genet 16(1):16–25

    Article  CAS  Google Scholar 

  4. Patel AP, Naik MR, Shah NM, Sharma NP, Parmar PH (2012) Prevalence of common hemoglobinopathies in Gujrat: an analysisof a large population screening programme. Natl J Community Med 3(1):112–116

    Google Scholar 

  5. Modell B, Darlison M (2008) Global epidemiology of hemoglobin disorder and derived service indicators. Bull World Health Organ 86:480–487

    Article  PubMed  PubMed Central  Google Scholar 

  6. Weatherall D (2011) The inherited disorders of hemoglobin: an increasingly neglected global health burden. Indian J Med Res 134(4):493–497

    PubMed  PubMed Central  Google Scholar 

  7. Balgir RS (2005) Spectrum of hemoglobinopathiesin the state of Orissa, India: a ten year cohort study. J Assoc Physicians India 53:1017–1018

    Google Scholar 

  8. Alam S, Singh A, Chakrabarty S, Mohanty R (2016) Spectrum of hemoglobinopathies in Odisha: an institutional study by CE-HPLC. Int J Med Sci Public Health 5:208–211

    Article  Google Scholar 

  9. Sachdev R, Dam AR, Tyagi G (2010) Detection of Hb variants and hemoglobinopathies in Indian population using HPLC: report of 2600 cases. Indian J Pathol Microbiol 53:57–62

    Article  PubMed  Google Scholar 

  10. Saha N, Banarjee B (1973) Hemoglobinopathies in the Indian subcontinent. Acta Genet Med Gemellol 22:117–138

    Article  CAS  PubMed  Google Scholar 

  11. Mondal SK, Mandal S (2016) Prevalence of thalassemia and hemoglobinopathy in eastern India: a 10-year high-performance liquid chromatography study of 119,336 cases. Asian J Transfus Sci 10:105–110

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Shrivastav A, Patel U, Joshi JR, Kaur A, Agnihotri AS (2013) Study of hemoglobinopathies and Hb variants in population of Western India using HPLC: a report of 7,000 cases. J Appl Hematol 4(3):104–109

    Article  Google Scholar 

  13. Manna AK, Dutta SK, Chatterjee A (2009) Relative incidence of different thalassaemias and haemoglobinopathies in South Bengal. J Indian Med Assoc 107:347–349

    PubMed  Google Scholar 

  14. Singh J, Saxena M, Ahmad F, Kumar A, Awasthi S, Dutta S (2016) Spectrum of hemoglobinopathies and thalassemias diagnosed on HPLC in a tertiary teaching hospital of northern India. Natl J Lab Med 5(3):70–75

    CAS  Google Scholar 

  15. Mukhopadhyay D, Saha K, Sengupta M, Mitra S, Datta C, Mitra PK (2015) Spectrum of hemoglobinopathies in West Bengal, India: a CE-HPLC study on 10,407 subjects. Indian J Hematol Blood Transfus 31(1):98–103

    Article  PubMed  Google Scholar 

  16. Mohanty D, Colah RB, Gorakshakar AC et al (2013) Prevalence of β-thalassemia and other hemoglobinopathies in six cities in India: a multicentre study. J Community Genet 4:33–42

    Article  CAS  PubMed  Google Scholar 

  17. Kar BC, Satpathy RK, Kulozik AE, Kulozik M, Sirr S, Serjeant BE (1986) Sickle cell disease in Orissa state, India. Lancet 328(8517):1198–1201

    Article  Google Scholar 

Download references

Funding

This study was not granted any fund.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rabindra Kumar Jena.

Ethics declarations

Conflict of interest

There is no conflict of interest.

Statement of Human Rights

The study was approved by institutional ethical committee and carried out in accordance with the Declaration of Helisinki.

Informed Consent

Informed consent was obtained from all patients.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ray, G.K., Jena, R.K. Spectrum of Hemoglobinopathies: A New Revelation in a Tertiary Care Hospital of Odisha. Indian J Hematol Blood Transfus 35, 513–517 (2019). https://doi.org/10.1007/s12288-018-1052-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12288-018-1052-8

Keywords

Navigation