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Relationship Between Haemostasis Parameters and Anxiety Under Examination Stress: A Pilot Study

Abstract

This work aims to clarify how blood coagulation parameters reflect mild stress response in males and females. Healthy student volunteers of both sexes were used in this pilot study. A new global sensitive assay of haemostasis, spatial thrombodynamics, along with conventional coagulometry approach were used to evaluate of blood coagulation parameters. Psychodiagnostics scales (according to Spielberger and Taylor) are employed to evaluate anxiety as stress-induced response. We have selected exam stress, which despite being a mild stressor may nevertheless cause somatic disorders. We provide the first evidence of a statistically significant increase in initial clot growth velocity in women, but not men, in response to exam stress. The exam situation produces higher situational anxiety in female volunteers, and so they express remarkable stress-induced haemostatic responses, including plasma- and platelet-based changes. In contrast, male volunteers do not express pronounced stress-induced changes in haemostasis, and only display a decrease in plateletcrit value and an increase in prothrombin time. Mild form of stress (exam) induces changes in some blood coagulation parameters. A statistically significant remarkable increase in Vinit value and some other plasma- and platelet-based parameters has been seen in female students (but not male ones) under exam stress.

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Abbreviations

Vinit :

The initial velocity of induced thrombosis

Vsteady :

The steady velocity of induced thrombosis

dSpeed :

The difference between the initial and steady velocity of induced thrombosis

PT:

Prothrombin time

INR:

International normalized ratio

APTT:

Activated partial thromboplastin time

PLT:

Absolute number of platelets

MPV:

The average platelets’ volume

PCT:

Thrombocrit

STAI:

State-trait anxiety inventory

TMAS:

Teilor’s Manifest Anxiety Scale

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Acknowledgements

The authors are grateful to Professor Dr. Fazly Ataullakhanov (Lomonosov Moscow State University and “HemaCore” Ltd) for the support with thrombodynamics studies and fruitful discussions. The work was supported and 2016-2018 Grant of Russian Institute of Advanced Study at the Moscow State Pedagogical University (to R.V.K.).

Funding

This work was funded by the subsidy allocated by the Russian Ministry of Education and Science, Grant # 19.9777.2017/8.9 to Kazan Federal University for the state assignment in the sphere of scientific activities.

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Correspondence to Renad Ibrahimovich Zhdanov.

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The authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards approved by the Local Ethics Committee of the Kazan State Medical University (6.21.06.18) and with the 1964 Helsinki declaration and its later amendments.

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Informed consent was obtained from all individual participants included in the study.

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Cite this article

Zhdanov, R.I., Kupriyanov, R.V., Zhdanova, S.I. et al. Relationship Between Haemostasis Parameters and Anxiety Under Examination Stress: A Pilot Study. Indian J Hematol Blood Transfus 34, 727–730 (2018). https://doi.org/10.1007/s12288-018-0980-7

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Keywords

  • Haemostasis
  • Blood coagulation
  • Anxiety
  • Gender
  • Stress
  • Thrombodynamics