Thrombolysis Using Tissue Plasminogen Activator: Experience from a Critical Care Setting

  • Amna Afzal Saeed
  • Qalab AbbasEmail author
  • Sidra Ishaque
  • Bushra Saeed
  • Anwar ul Haque
Short Communication


To describe the experience of thrombolysis using tissue plasminogen activator (tPA) in critically ill children admitted to the pediatric intensive care unit (PICU), retrospective review of medical records of all children (1 month–16 years), who were admitted in PICU since January 2014 to December 2017 and received systemic tPA for thrombolysis was done. Data was collected on a structured proforma and included thrombus location, tPA dose and duration, outcome (resolution, survival) and complications (bleeding). Total 9 patients (7 males, 2 females) received systemic tPA therapy for thrombolysis with mean age of 74.64 ± 69.58 months. Two patients had thrombus in femoral artery, 3 in IVC and 4 had intra-cardiac thrombosis. Median number of doses was 2 with a range of 1–5 doses. Complete resolution of the clot was noted in all except one patient. A standard starting dose of 0.01 mg/kg/h was used in all patients. Only one patient developed melena after TPA therapy which self-resolved. Systemic tPA therapy was very safe in pediatric critically ill patients and was effective for thrombolysis and did not show any adverse effects in children with varying underlying diagnosis.


Systemic tPA Children Thrombolysis 


Compliance with Ethical Standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

Aga Khan University 4893-PED-ERC-17.


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Copyright information

© Indian Society of Hematology and Blood Transfusion 2018

Authors and Affiliations

  1. 1.Medical CollegeAga Khan UniversityKarachiPakistan
  2. 2.Department of Pediatrics and Child HealthAga Khan University HospitalKarachiPakistan
  3. 3.Department of PediatricsThe Indus HospitalKarachiPakistan

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