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Peripheral Blood Monocyte Count is a Predictor of Successful Peripheral Blood Stem Cell Harvest After Chemo-Mobilization in Patients with Malignant Lymphoma

  • Yoshimi Ishii
  • Shin Fujisawa
  • Chika Nigauri
  • Taiki Ando
  • Taisei Suzuki
  • Eriko Ogusa
  • Kazuho Miyashita
  • Kenji Motohashi
  • Hideaki Nakajima
Correspondence

High-dose therapy (HDT) followed by autologous hematopoietic stem cell transplantation (ASCT) is useful for patients with chemosensitive refractory/relapsed non-Hodgkin lymphoma, Hodgkin lymphoma, or newly diagnosed mantle cell lymphoma (MCL). For successful ASCT, infusion of an adequate number of CD34 positive cells is important. However, the best strategy for harvesting peripheral blood stem cells (PBSCs) and the factors correlated with effective mobilization are still unknown. Here, we retrospectively analyzed the factors correlated with optimal PBSCs mobilization.

Between November 2006 and December 2015, 36 patients diagnosed with malignant lymphoma underwent harvesting of PBSCs at Yokohama City University Medical Center. They were judged as suitable for HDT followed by ASCT. PBSCs were mobilized using chemotherapy followed by G-CSF (lenograstim and filgrastim) or G-CSF alone at the physician’s discretion. We aimed to obtain 2.0 × 106/kg CD34 positive cells in total. All patients...

Keywords

Lymphoma Harvest Stem cell mobilization Peripheral blood monocyte count 

Notes

Compliances with Ethical Standard

Conflict of interest

The author declares that he/she has no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Copyright information

© Indian Society of Haematology & Transfusion Medicine 2017

Authors and Affiliations

  • Yoshimi Ishii
    • 1
  • Shin Fujisawa
    • 1
  • Chika Nigauri
    • 1
  • Taiki Ando
    • 1
  • Taisei Suzuki
    • 1
  • Eriko Ogusa
    • 1
  • Kazuho Miyashita
    • 1
  • Kenji Motohashi
    • 1
  • Hideaki Nakajima
    • 2
  1. 1.Department of HematologyYokohama City University Medical Center, 4-57, Urafune-choYokohamaJapan
  2. 2.Department of Hematology and Clinical ImmunologyYokohama City University School of MedicineYokohamaJapan

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