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Occurrence of Double Monoclonal Bands on Protein Electrophoresis: An Unusual Finding

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Abstract

Various techniques of protein electrophoresis are used for detection of monoclonal proteins/paraproteins in serum and/or urine of patients with monoclonal gammopathies. These are detected as the so-called ‘M’ bands (monoclonal bands) on serum protein electrophoresis and/or immunofixation electrophoresis. In most cases, a single M-band is detected. However, more than one M-band can be detected in the samples of a minor proportion of patients. This condition is termed as ‘double gammopathy’ or ‘biclonal gammopathy’. A knowledge of such an unusual occurrence is essential for recognition and appropriate interpretation of this entity.

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Authors and Affiliations

  1. Department of Immunopathology, Level 4, Research Block A, Postgraduate Institute of Medical Education and Research, Sector-12, Chandigarh, 160012, India

    Vishrut K Srinivasan, Priyanka Bhagat, Frainey Bansal & Seema Chhabra

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  1. Vishrut K Srinivasan
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  2. Priyanka Bhagat
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  3. Frainey Bansal
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  4. Seema Chhabra
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Correspondence to Seema Chhabra.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Srinivasan, V.K., Bhagat, P., Bansal, F. et al. Occurrence of Double Monoclonal Bands on Protein Electrophoresis: An Unusual Finding. Indian J Hematol Blood Transfus 32 (Suppl 1), 184–188 (2016). https://doi.org/10.1007/s12288-015-0622-2

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  • DOI: https://doi.org/10.1007/s12288-015-0622-2

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