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Primary Intraocular Diffuse Large B-cell Lymphoma: Diagnostic Difficulties in Deep Retinal Infiltrations with Vitritis

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Purpose

Primary intraocular lymphoma (PIOL) is a rare malignancy with an aggressive clinical course. It is usually considered as a subset of primary central nervous system lymphoma. Differential diagnosis should include infectious and non-infectious aetiologies, particularly the common masqueraders sarcoidosis, tuberculosis, viral retinitis and syphilis.

Patient

The article presents a case of bilateral vitreoretinal lymphoma manifesting as uveitis and vitritis resistant to corticosteroid therapy. The final diagnosis was based on a retinal biopsy.

Results

The patient was successfully treated with systemic and local therapy. Long-term complete remission (CR) was reached. The relapse of diffuse large B-cell lymphoma was revealed in the frontal left lobe after 48 months of CR duration.

Conclusion

The diagnosis of PIOL is always very difficult. Cooperation of pathologists, ophthalmologists and hematologists is required for a quick and accurate diagnosis. Local and systemic treatment is needed to achieve CR, but the relapse rate remains very high.

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Author information

Authors and Affiliations

  1. Department and Clinic of Hematology, Blood Neoplastic Disorders and Bone Marrow Transplantation, Wroclaw Medical University, 4` Pasteur St, 50-367, Wroclaw, Poland

    Katarzyna Kapelko-Slowik, Donata Urbaniak-Kujda, Stanislaw Potoczek, Jaroslaw Dybko & Monika Biernat

  2. Department of Ophthalmology, Wroclaw Medical University, Wroclaw, Poland

    Anna Turno-Krecicka & Miroslaw Slowik

  3. Department of Microbiology, Wroclaw Medical University, Wroclaw, Poland

    Monika Biernat

  4. Wroclaw Physiotherapy College, Wroclaw, Poland

    Donata Urbaniak-Kujda

Authors
  1. Katarzyna Kapelko-Slowik
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  2. Donata Urbaniak-Kujda
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  3. Anna Turno-Krecicka
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  4. Stanislaw Potoczek
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  5. Jaroslaw Dybko
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  6. Monika Biernat
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  7. Miroslaw Slowik
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Corresponding author

Correspondence to Katarzyna Kapelko-Slowik.

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Conflict of interest

The authors declare that they have no conflict of interest

Human and Animal Rights

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from the patient included in the study.

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Kapelko-Slowik, K., Urbaniak-Kujda, D., Turno-Krecicka, A. et al. Primary Intraocular Diffuse Large B-cell Lymphoma: Diagnostic Difficulties in Deep Retinal Infiltrations with Vitritis. Indian J Hematol Blood Transfus 32 (Suppl 1), 143–147 (2016). https://doi.org/10.1007/s12288-015-0599-x

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  • DOI: https://doi.org/10.1007/s12288-015-0599-x

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