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Leukemia in Patients with Klinefelter Syndrome: A Report of Two Cases

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Abstract

Klinefelter syndrome (KS) is a chromosome abnormality characterized by a 47, XXY karyotype associated with hypogonadism and infertility. We present two cases of leukemia in patients with KS. The first patient presented with acute promyelocytic leukemia. He relapsed after the end of treatment. The second patient was diagnosed with chronic myeloid leukemia. Treatment with imatinib failed and the patient presented with myeloid blast crisis.

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Acknowledgements

Dr. Wiem AYED, Olfa KILANI and Ahlem AMOURI made the cytogenetic analysis for the two patients.

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Authors and Affiliations

  1. Department of Hematology, Aziza Othmana University Hospital, Place du gouvernement, la Kasbbah, 1008, Tunis, Tunisia

    M. Bchir, H. Ben Neji, S. Kefi, M. Zarrouk & B. Meddeb

  2. Laboratory of Histology and Cytogenetics, Department of Histology and Cytogenetics, Faculty of Medicine of Tunis, Institut Pasteur de Tunis, El Manar Tunis University, 13, Place Pasteur, BP74, 1002, Tunis, Tunisia

    W. Ayed, O. Kilani, H. Guermani, S. Hentati & A. Amouri

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  1. M. Bchir
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  2. W. Ayed
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  3. H. Ben Neji
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  4. O. Kilani
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  5. S. Kefi
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  6. M. Zarrouk
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  7. H. Guermani
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  8. S. Hentati
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  9. A. Amouri
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  10. B. Meddeb
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Correspondence to M. Bchir.

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Bchir, M., Ayed, W., Neji, H.B. et al. Leukemia in Patients with Klinefelter Syndrome: A Report of Two Cases. Indian J Hematol Blood Transfus 32 (Suppl 1), 66–68 (2016). https://doi.org/10.1007/s12288-015-0590-6

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  • DOI: https://doi.org/10.1007/s12288-015-0590-6

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