Frequency of West Nile Virus Infection in Iranian Blood Donors

Abstract

West Nile virus (WNV) can be transmitted by blood transfusions and organ transplants. This study was a retrospective study which was performed in Blood Transfusion Center to evaluate the WNV infection in blood donors in Iran. A total of 540 blood samples were taken from volunteer healthy donors who referred for blood donation to Chabahar Blood Center. The presence of WNV was studied by detecting immunoglobulin G (IgG) WNV by enzyme linked immune sorbent assay (ELISA). Demonstration of elevated WNV IgG confirmed by immunoflouorescence assay (IFA) Euroimmun kit. Out of the 540 samples 17.96 % (97 cases) were seropositive by ELISA and 1.48 % (8 cases) was seropositive by IFA. This means that 8.24 % of ELISA seropositive samples were confirmed by IFA. Special attention should be paid to criteria of donor selection, albeit positive results may be due to a previous infection in these donors.

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References

  1. 1.

    Lim SM, Koraka P, Osterhaus AD, Martina BE (2011) West Nile virus: immunity and pathogenesis. Viruses 3(6):811–828

    Article  PubMed  PubMed Central  Google Scholar 

  2. 2.

    Smithburn KC, Hughes TP, Burke AW, Paul JH (1940) A neurotropic virus isolated from the blood of a native of Uganda. Am J Trop Med 20:471–492

    Google Scholar 

  3. 3.

    The Center for Food Security and Public Health (CFSPH) (2009) West Nile virus infection. http://www.cfsph.iastate.edu/Factsheets/pdfs/west_nile_fever.pdf. Accessed 23 May 2013

  4. 4.

    Kakaiya R (2006) Transfusion transmitted West Nile virus infection update. Institute for transfusion medicine. http://www.itxm.org/tmu/tmu2006/issue2RK06.pdf. Accessed 23 May 2013

  5. 5.

    Sotelo E, Gutierrez-Guzmán AV, Amo Jd et al (2011) Pathogenicity of two recent Western Mediterranean West Nile virus isolates in a wild bird species indigenous to Southern Europe: the red-legged partridge. Vet Res 42(1):11–18

    Article  PubMed  PubMed Central  Google Scholar 

  6. 6.

    Pealer LN, Marfin AA, Petersen LR et al (2003) Transmission of West Nile virus through blood transfusion in the United States in 2002. N Engl J Med 349(13):1236–1245

    CAS  Article  PubMed  Google Scholar 

  7. 7.

    Fereidouni SR, Ziegler U, Linker S et al (2011) West Nile virus monitoring in migrating and resident water birds in Iran: are common coots main reservoirs of the virus in wetlands? Vector Borne Zoonotic Dis 11(10):1377–1381

    Article  PubMed  Google Scholar 

  8. 8.

    Wallace MR, Hale BR, Utz GC et al (2002) Endemic infectious diseases of Afghanistan. Clin Infect Dis 34(Suppl 5):S171–S207

    Article  PubMed  Google Scholar 

  9. 9.

    Bryan JP, Igbal M, Ksiazek TG et al (1996) Prevalence of sand fly fever, West Nile, Crimean-Congo hemorrhagic fever, and leptospirosis antibodies in Pakistani military personnel. Mil Med 161(3):149–153

    CAS  PubMed  Google Scholar 

  10. 10.

    Batieha A, Saliba EK, Graham R et al (2000) Seroprevalence of West Nile, Rift Valley, and sandfly arboviruses in Hashimiah, Jordan. Emerg Infect Dis 6(4):358–362

    CAS  Article  PubMed  PubMed Central  Google Scholar 

  11. 11.

    Ozkuli A, Yildirm Y, Pinar D et al (2006) Serological evidence of West Nile Virus (WNV) in mammalian species in Turkey. Epidemiol Infect 134(4):826–829

    Article  Google Scholar 

  12. 12.

    Kalaycioglu H, Korukluoglu G, Ozkul A et al (2012) Emergence of West Nile virus infections in humans in Turkey, 2010 to 2011. Eurosurveillance 17(21):20182

    PubMed  Google Scholar 

  13. 13.

    Sharifi Z, Shooshtari MM, Talebian A (2010) A study of West Nile virus infection in Iranian blood donors. Ach Iran Med 13(1):1–4

    Google Scholar 

Download references

Acknowledgments

The authors would like to thank the Research Center of the IBTO and Queensland University of Technology, Australia for supporting this study. We also wish to express our thanks to all employees of the QC laboratory of the IBTO who have been a great source of inspiration and technical expertise.

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Correspondence to Afsaneh Aghaie.

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The authors declare that there is no conflict of interest.

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Communicated by Haraprasad Pati.

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Aghaie, A., Aaskov, J., Chinikar, S. et al. Frequency of West Nile Virus Infection in Iranian Blood Donors. Indian J Hematol Blood Transfus 32, 343–346 (2016). https://doi.org/10.1007/s12288-015-0567-5

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Keywords

  • West Nile virus (WNV)
  • Blood donor
  • Iran
  • Donor selection
  • Epidemiology
  • Enzyme linked immune sorbent assay (ELISA)
  • Immunoflouorescence assay (IFA)