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Quantification of Transfusion Recipients at Risk of Receiving Hepatitis B Virus-Contaminated Blood Components: A Korean Study

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Although there are lots of studies about the risk for the hepatitis B virus infection such as the residual risk for donated blood, there is no research on the risk of HBV infection, from the viewpoint of recipients in Korea. Using the data about HBsAg status of donated blood in 2008 and 2009, the distribution of blood components from the claim data of health insurance in 2009, the distribution of HBsAg and HBsAb of recipients, and some assumptions, we quantified the number of recipients in Korea that might be expected to receive HBV-contaminated blood components, as a proxy index for HBV infection by transfusion in 2009. Of the 376,211 recipients, the number who might be expected to receive blood components with HBV in 2009 was 23.2 (95 % CI 13.6, 36.8) in the basic model, 43.2 (95 % CI 25.4, 68.7) in extended model I, 55.2 (95 % CI 32.5, 87.7) in extended model II and 101.6 (95 % CI 59.8, 161.4) in extended model III. The number of HBV-positive samples per 100,000 transfused units was 0.6 in the basic model (95 % CI 0.3, 0.9), 1.1 in extended model I (95 % CI 0.6, 1.8), 1.4 in extended model II (95 % CI 0.8, 2.2), and 2.6 in extended model III (95 % CI 1.5, 4.1). This study showed that a few recipients might receive HBV-contaminated blood component by transfusion. These results could be used as a scientific evidence for health policy on HBV transfusion infection.

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Acknowledgments

This work was supported by Konkuk University in 2014.

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Authors and Affiliations

  1. Department of Preventive Medicine, School of Medicine, Konkuk University, Achasanro 263, Gwangjin-gu, Seoul, 143-701, Korea

    Kunsei Lee, Hyeongsu Kim, Sounghoon Chang, Vitna Kim & Hyoseon Jeong

  2. Department of Laboratory Medicine, School of Medicine, Konkuk University, Seoul, Korea

    Mina Hur

  3. Labgenomics Clinical Laboratories, Seongnam, Korea

    Dong Hee Seo

  4. Division of Epidemic Intelligence Service, Korea Centers for Disease Control & Prevention, Cheongju, Korea

    SangWon Lee

  5. Department of Nursing, College of Medicine, Hallym University, Chuncheon, Korea

    Eun Jung Kim

  6. Department of Public Health Administration, Hanyang Women’s University, Seoul, Korea

    Eunyoung Shin

  7. Division of Infectious Disease Control, Korea Centers for Disease Control & Prevention, Cheongju, Korea

    Young Tack Kim

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  1. Kunsei Lee
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  2. Hyeongsu Kim
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  3. Sounghoon Chang
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  4. Mina Hur
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  5. Vitna Kim
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  8. SangWon Lee
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Correspondence to Hyeongsu Kim.

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Lee, K., Kim, H., Chang, S. et al. Quantification of Transfusion Recipients at Risk of Receiving Hepatitis B Virus-Contaminated Blood Components: A Korean Study. Indian J Hematol Blood Transfus 32, 312–319 (2016). https://doi.org/10.1007/s12288-015-0564-8

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  • DOI: https://doi.org/10.1007/s12288-015-0564-8

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