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Effective Treatment of a Childhood Blastic Plasmacytoid Dendritic Cell Neoplasm with a Cutaneous Tumor Alone by Stem Cell Transplantation with Reduced Intensity Conditioning

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Pediatric blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematological malignancy that has an extremely poor prognosis despite the use of intensive chemotherapy. Recently, treatment of BPDCN with bone marrow transplantation (BMT) using myeloablative conditioning has been reported to increase survival in adults. We report a 9-year-old girl with cutaneous BPDCN who was successfully treated with combination chemotherapy followed by BMT using reduced intensity conditioning (RIC), without any adverse complications. The success of this treatment regimen suggests that BMT with RIC may be a feasible option for treating children with cutaneous BPDCN.

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Acknowledgments

We thank Atsuko Nakagawa, MD, Department of pathology, National Center for Child Health and Development, Tokyo, Japan, for the histological examination and the immunohistochemical staining.

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Authors and Affiliations

  1. Department of Pediatrics, Hiroshima University Graduate School of Biomedical & Health Sciences, Hiroshima, Japan

    Maiko Shimomura, Takaki Asano, Aya Furue, Mizuka Miki, Yasuhiko Sera, Hiroshi Kawaguchi, Kazuhiro Nakamura & Masao Kobayashi

  2. Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1-1-1 Minamikogushi, Ube, 755-8505, Japan

    Maiko Shimomura

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  1. Maiko Shimomura
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  2. Takaki Asano
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  3. Aya Furue
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  5. Yasuhiko Sera
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  6. Hiroshi Kawaguchi
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  7. Kazuhiro Nakamura
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  8. Masao Kobayashi
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Correspondence to Maiko Shimomura.

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Shimomura, M., Asano, T., Furue, A. et al. Effective Treatment of a Childhood Blastic Plasmacytoid Dendritic Cell Neoplasm with a Cutaneous Tumor Alone by Stem Cell Transplantation with Reduced Intensity Conditioning. Indian J Hematol Blood Transfus 32 (Suppl 1), 26–31 (2016). https://doi.org/10.1007/s12288-015-0543-0

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  • DOI: https://doi.org/10.1007/s12288-015-0543-0

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