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Risk Factors for Transfusion Transmissible Infections Elicited on Post Donation Counselling in Blood Donors: Need to Strengthen Pre-donation Counselling


Donor notification and counselling transforms the legal and ethical requirement of disclosure of transfusion transmissible infection (TTI) in a blood donor into practice. The present study was done to assess the response to the disclosure of TTI reactivity results in blood donors, assess the risk factors in blood donors and follow the compliance of the disclosure and clinical referral in a population of blood donors who are difficult to convince that they may be harbouring infections apparently in a healthy state today but with possible clinical disease consequences in the future. A retrospective study was conducted from April 2011 to November 2012. Screening was done using third generation ELISA kits used according to the manufacturer’s directions; these kits were approved for use in blood banks by the Drug Controller General of India. Those testing repeat reactive were referred for further confirmation and management. The total number of TTI reactive donors was 787 (0.93 %, N = 83,865). The observed response rate in the present study is 21.6 % (167, N = 787). The risk factors for acquiring infections in TTI reactive donors were statistically significant history of high risk behaviour (20.3 %) for human immunodeficiency virus infection and history of jaundice in themselves, family or close contacts (16.1 %) for hepatitis B virus infection. One hundred and ten (65.8 %) of the referred donors were on outpatient clinical care when post-referral follow up was conducted. The study emphasises on continuing sensitization of blood donation camp organisers to the need of privacy during blood donor selection. The study also stresses the need to strengthen the pre-donation counselling at outdoor blood donation at the same time raise awareness amongst blood donors about the importance of post-donation counselling and follow up.

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  1. Bianco C, Kessler D (1994) Donor notification and counseling. Management of blood donors with positive test results. Vox Sang 67(Suppl 3):255–259

    PubMed  Article  Google Scholar 

  2. Choudhury LP, Tetali S (2008) Notification of transfusion transmitted infection. Indian J Med Ethics 5:58–60

    PubMed  Google Scholar 

  3. Miller R, Hewitt PE, Warwick R, Moore MC, Vincent B (1998) Review of counselling in a transfusion service: the London (UK) experience. Vox Sang 74:133–139

    CAS  PubMed  Article  Google Scholar 

  4. The Drugs and Cosmetics Act, 1940 and the Drugs and Cosmetics Rules, 1945, as amended up to 30th June, 2005. Schedule F. Part XIIB. Government of India. Ministry of Health and Family Welfare. Department of Health. pp 268–288. Accessed 4 April 2013

  5. National AIDS Control organisation (2007) An action plan for blood safety. National AIDS Control organisation. Ministry of Health and Family Welfare. Government of India, p 31–32. Accessed 8 May 2013

  6. Mudur G (2002) India announces plan to inform HIV infected blood donors. BMJ 325:1380

    PubMed Central  PubMed  Article  Google Scholar 

  7. Mangla B (1993) India: HIV-positive blood donors. Lancet 341:1527–1528

    CAS  PubMed  Article  Google Scholar 

  8. National AIDS Control Organization (2007) Manual on quality standards for HIV testing laboratories. National AIDS Control Organization, Ministry of Health and Family Welfare, Government of India, pp 9–11. Accessed 8 May 2013

  9. Kaur G, Kaur P, Basu S, Kaur R, Sharma S (2013) Donor notification and counseling: experience and challenges. Transfus Apheres Sci 49:291–294. doi:10.1016/j.transci.2013.05.005

    Article  Google Scholar 

  10. Agarwal N (2012) Response rate of blood donors in the Uttarakhand region of India after notification of reactive test results on their blood samples. Blood Transfus 5:1–3. doi:10.2450/2012.0100-12

    Google Scholar 

  11. Patel P, Patel S, Bhatt J, Bhatnagar N, Gajjar M (2012) Evaluation of response to donor notification of reactive transfusion transmitted infections (TTIs) result. NJIRM 3:20–25

    Google Scholar 

  12. Suman FR, Krishnamoorthy R, Panicker VK, Alexander S, Ida S (2011) Is it essential to inform the positive donor? A 2-year study in a tertiary care hospital. J Nat Sci Biol Med 2:185–187. doi:10.4103/0976-9668.92330

    PubMed Central  PubMed  Article  Google Scholar 

  13. Kleinman S, Wang B, Wu Y, Glynn SA, Williams A, Nass C et al (2004) Retrovirus epidemiology donor study. The donor notification process from the donor’s perspective. Transfusion 44:658–666

    PubMed  Article  Google Scholar 

  14. Kerzman H, Green MS, Shinar E (2009) Predictors for non-compliance of notified hepatitis C virus-positive blood donors with recommendation to seek medical counselling. Vox Sang 96:20–28. doi:10.1111/j.1423-0410.2008.01111.x

    CAS  PubMed  Article  Google Scholar 

  15. Roshan TM, Rosline H, Ahmed SA, Rappiah M, Khattak MN (2009) Response rate of Malaysian blood donors with reactive screening test to transfusion medicine unit calls. Southeast Asian J Trop Med Public Health 40:1315–1321

    CAS  PubMed  Google Scholar 

  16. Li C, Xiao X, Yin H, He M, Li J, Dai Y et al (2010) Prevalence and prevalence trends of transfusion transmissible infections among blood donors at four Chinese regional blood centers between 2000 and 2010. J Transl Med 10:176. doi:10.1186/1479-5876-10-176

    Article  Google Scholar 

  17. Nagalo MB, Sanou M, Bisseye C, Kaboré MI, Nebie YK, Kienou K et al (2011) Seroprevalence of human immunodeficiency virus, hepatitis B and C viruses and syphilis among blood donors in Koudougou (Burkina Faso) in 2009. Blood Transfus 9:419–424. doi:10.2450/2011.0112-10

    PubMed Central  PubMed  Google Scholar 

  18. Tessema B, Yismaw G, Kassu A, Amsalu A, Mulu A, Emmrich F et al (2010) Seroprevalence of HIV, HBV, HCV and syphilis infections among blood donors at Gondar University Teaching Hospital, Northwest Ethiopia: declining trends over a period of five years. BMC Infect Dis 10:111. doi:10.1186/1471-2334-10-111

    PubMed Central  PubMed  Article  Google Scholar 

  19. Schreiber GB, Glynn SA, Busch MP, Sharma UK, Wright DJ, Kleinman SH (2001) Retrovirus epidemiology donor study. Incidence rates of viral infections among repeat donors: are frequent donors safer? Transfusion 41:730–735

    CAS  PubMed  Article  Google Scholar 

  20. Doll LS, Petersen LR, White CR, Ward JW (1991) Human immunodeficiency virus type 1-infected blood donors: behavioral characteristics and reasons for donation. The HIV Blood Donor Study Group. Transfusion 31:704–709

    CAS  PubMed  Article  Google Scholar 

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We acknowledge that the study could not delineate the various reasons for the significantly high number of repeat donors noted in the initial reactive category. This study was based upon retrospective data review, where the discriminating details of previous donations were not readily available.

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There is no conflict of interest amongst any of the authors and no affiliation with any funding source.

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Correspondence to Suchet Sachdev.

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Sachdev, S., Mittal, K., Patidar, G. et al. Risk Factors for Transfusion Transmissible Infections Elicited on Post Donation Counselling in Blood Donors: Need to Strengthen Pre-donation Counselling. Indian J Hematol Blood Transfus 31, 378–384 (2015).

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  • Blood donor
  • Notification
  • Counselling
  • Transfusion transmissible infection