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Improvement of Chronic Osteomyelitis After Granulocyte Colony Stimulating Factor

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Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Background: chronic osteomyelitis represents a persistent bone and bone marrow infection easy to diagnose in the presence of pain, erythema, swelling, and a draining sinus but more difficult to detect in the absence of the preceding features and with a painful orthopaedic prosthesis. Case Description: we report upon an elderly gentleman with myelodysplasia requiring revision surgery for a fractured prosthetic left knee. He had clinical, laboratory, and radiological features of chronic osteomyelitis that improved only with administration of granulocyte colony stimulating factor (G-CSF). Literature Review: G-CSF has been successfully employed to treat resistant osteomyelitis in three young patients with primary defects of monocyte and neutrophil killing. A randomized trial confirmed the efficacy of G-CSF in the treatment of chronic osteomyelitis in twenty patients with diabetic foot ulcers and a rat model confirmed the efficacy of G-CSF in acute osteomyelitis. Clinical Relevance: our case highlights the usefulness of G-CSF treatment for immune suppressed patients with resistant chronic osteomyelitis.

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None declared.

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Authors and Affiliations

  1. Departments of General Medicine, Airedale General Hospital, Airedale Foundation Trust, Skipton Road, Steeton, BD20 6TD, UK

    Michael I. Pearce

  2. Departments of Haematology/Rheumatology, Airedale Foundation Trust, Steeton, UK

    Ann Cuthbert & Paul R. J. Ames

  3. Departments of Radiology, Airedale Foundation Trust, Steeton, UK

    Guy Porter

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  1. Michael I. Pearce
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  2. Ann Cuthbert
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  3. Guy Porter
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  4. Paul R. J. Ames
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Correspondence to Michael I. Pearce.

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Pearce, M.I., Cuthbert, A., Porter, G. et al. Improvement of Chronic Osteomyelitis After Granulocyte Colony Stimulating Factor. Indian J Hematol Blood Transfus 29, 48–51 (2013). https://doi.org/10.1007/s12288-011-0127-6

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  • DOI: https://doi.org/10.1007/s12288-011-0127-6

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