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Is red cell from an otherwise healthy G6PD-deficient donor efficient for transfusion to fauvism patients?

Abstract

Aim

Glucose-6-Phosphate dehydrogenase (G6PD) deficiency is the most common X-linked defect of enzyme pathways in human. The aim of this study was to inspect the efficacy of G6PD deficient red cell transfusion to G6PD patients, who were admitted for hemolysis after Broad bean ingestion, and to find out whether prolong management program and retransfusion are needed as severe hemolysis would take place.

Methods

This was a cross-sectional study, which was performed on patients admitted to hospital due to hemolytic anemia after broad bean ingestion in Jahrom and Shiraz medical school hospitals on February and March 2007. 2ml samples of transfusion blood bags, were sent to the laboratory in order to investigate the G6PD enzyme sufficiency. Hemoglobin level was checked six hours after blood transfusion. We compared the amount of hemoglobin level elevation after transfusion in patients received G6PD sufficient and G6PD deficient red cell using independent sample t-test.

Result

In 114 transfused bags, 14 bags (12.3%) were G6PD deficient. We divided patients into two groups. Group A received G6PD sufficient red cell and group B were transfused with G6PD deficient red cell. Hemoglobin level was significantly raised after transfusion of red cell in each group. The amount of hemoglobin elevation was more in group A in comparison to group B.

Conclusion

Based on our study results, proper hemoglobin level would be achieved using non G6PD deficient red cell for transfusion to G6PD deficient patients.

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Correspondence to Omid Reza Zekavat.

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Zekavat, O.R., Karimi, M. & Rahmanian, F. Is red cell from an otherwise healthy G6PD-deficient donor efficient for transfusion to fauvism patients?. Indian J Hematol Blood Transfus 25, 23–26 (2009). https://doi.org/10.1007/s12288-009-0005-7

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Keywords

  • Glucose-6-Phosphate dehydrogenase enzyme
  • G6PD deficiency
  • Hemolysis
  • Blood transfusion