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An analysis of 8 cases of factor X deficiency

  • Nilam M. Shah
  • Ashwin P. PatelEmail author
Original Article

Abstract

Background

Factor X deficiency is a rare coagulation defect. There are occasional reports of factor X deficiency from India. Difficulty in accurate diagnosis and non-availability of ideal treatment is discussed.

Methods

Eight cases of factor X deficiency, diagnosed from 1992 to 2007 are reported here

Results

Seven were male while one was female. Seven patients were symptomatic from early childhood. One patient became symptomatic from 18 years of age. Factor X assay was done in 4 patients, 3 had severe deficiency and one had mild deficiency. One patient had associated factor IX deficiency. Three patients had repeated bleeding episodes requiring multiple transfusions. Two patients had intracranial bleed and one had umbilical cord bleeding at birth. There was no mortality. No patient received prophylactic transfusion.

Conclusions

Factor X deficiency is a rare coagulation defect. Hereditary deficiency should be distinguished from acquired deficiency. CNS, joints and skin are the common sites of bleeding.

Keywords

Factor X deficiency Stuart factor Multiple factor deficiency Vitamin K Prothrombin complex concentrate Fresh frozen plasma 

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Copyright information

© Indian Society of Haematology & Transfusion Medicine 2008

Authors and Affiliations

  1. 1.Saumrut laboratoryAhmedabadIndia
  2. 2.Consultant HaematologistAhmedabadIndia

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