Zusammenfassung
Die Therapie von Lippen‑, Kiefer‑, Gaumen-Spalten erfordert eine Vielzahl interdisziplinär abgestimmter Behandlungsschritte. Im Rahmen des Rehabilitationskomplexes dieser Fehlbildungen besteht insbesondere um die Kieferspaltosteoplastik eine rege, teils kontroverse Debatte hinsichtlich der richtigen Behandlungsmodalitäten. Dieser Übersichtsartikel stellt die literaturbasierten Erkenntnisse zu Operationszeitpunkt und Entnahmeregion im Rahmen der Kieferspaltosteoplastik dar und soll eine Diskussion zur primären Kalottenosteoplastik anstoßen. Bei der Wahl des optimalen Operationszeitpunkts zur Rekonstruktion einer Kieferspalte ist die primäre Kieferspaltosteoplastik dann indiziert, wenn sie in der Phase des Durchbruchs des lateralen spaltnahen Milchinzisivus die osteogene Potenz dieses Vorgangs für eine optimale Ausformung des Alveolarfortsatzes nutzen kann. Zusätzlich sollte die Spaltbreite durch die therapeutische Vorbehandlung des Lippenspaltverschlusses nur noch wenige Millimeter betragen. Die Kalottenosteoplastik eignet sich insbesondere in diesen Fällen mit leichten Vorteilen bei der Entnahmemorbidität gegenüber der Beckenkammentnahme.
Abstract
Treatment of cleft lip and palate requires multiple interdisciplinary treatment steps. Concerning rehabilitation of this deformity, there is a heightened and in part controversial debate regarding the correct treatment modalities, particularly for alveolar cleft reconstruction. The aim of this review article is to present the literature-based findings for the timing of surgery and the donor site for alveolar cleft repair and to provide a basis for discussion of primary alveoloplasty with calvarial bone. Regarding optimal timing for osseous reconstruction of the alveolus in cleft lip and palate management, primary alveolar cleft repair is indicated during eruption of the cleft-proximal lateral incisor to benefit from the osteogenic potency of this process, thus promoting optimal stabilization of the alveolar process. Additionally, the width of the alveolar cleft should be minimalized by the therapeutic pretreatment of cleft lip closure to a few millimetres. The calvarial bone graft is particularly suitable in these cases, with slight advantages in donor site morbidity compared to the iliac crest.
Literatur
Derijcke A, Eerens A, Carels C (1996) The incidence of oral clefts: a review. Br J Oral Maxillofac Surg 34(6):488–494
Matsunaka E, Ueki S, Makimoto K (2015) Impact of breastfeeding or bottle-feeding on surgical wound dehiscence after cleft lip repair in infants: a systematic review protocol. JBI Database System Rev Implement Rep 13(10):3–11
Fan D, Wu S, Liu L, Xia Q, Tian G, Wang W, Ye S, Wang L, Rao J, Yang X, Yu Z, Xin L, Li S, Duan Z, Zhang T, Wu S, Guo X, Liu Z (2018) Prevalence of non-syndromic orofacial clefts: based on 15,094,978 Chinese perinatal infants. Oncotarget 9(17):13981–13990
Paaske EB, Garne E (2018) Epidemiology of orofacial clefts in a Danish county over 35 years – Before and after implementation of a prenatal screening programme for congenital anomalies. Eur J Med Genet. https://doi.org/10.1016/j.ejmg.2018.05.016
Alhayyan WA, Pan SC, AlQatami FM (2018) Birth Prevalence of Orofacial Clefts in Kuwait From Hospital-Based Registration: Retrospective Study. Cleft Palate Craniofac J. https://doi.org/10.1177/1055665618766059
Butts SC, Reynolds S, Gitman L, Patel P, Joseph M (2018) Patterns of Orofacial Clefting in new York city from 1983 to 2010: trends by racial background, birthplace, and public health strategies. Cleft Palate Craniofac J. https://doi.org/10.1177/1055665618770192
Sarmiento K, Valencia S, Gracia G, Hurtado-Villa P, Zarante I (2018) Clinical and Epidemiologic description of Orofacial clefts in Bogota and Cali, Colombia, 2001–2015. Cleft Palate Craniofac J 55(4):517–520
Higashi H, Barendregt JJ, Kassebaum NJ, Weiser TG, Bickler SW, Vos T (2015) The burden of selected congenital anomalies amenable to surgery in low and middle-income regions: cleft lip and palate, congenital heart anomalies and neural tube defects. Arch Dis Child 100(3):233–238
Bell JC, Raynes-Greenow C, Bower C, Turner RM, Roberts CL, Nassar N (2013) Descriptive epidemiology of cleft lip and cleft palate in Western Australia. Birth Defects Res Part A Clin Mol Teratol 97(2):101–108
Mossey PA, Little J, Munger RG, Dixon MJ, Shaw WC (2009) Cleft lip and palate. Lancet 374(9703):1773–1785
Hernigou P (2017) History of clubfoot treatment; part III (twentieth century): back to the future. Int Orthop 41(11):2407–2414
Thiele OC, Kreppel M, Dunsche A, Eckardt AM, Ehrenfeld M, Fleiner B, Gassling V, Gehrke G, Gerressen M, Gosau M, Grobe A, Hassfeld S, Heiland M, Hoffmeister B, Holzle F, Klein C, Kruger M, Kubler AC, Kubler NR, Kuttenberger JJ, Landes C, Lauer G, Martini M, Merholz ET, Mischkowski RA, Al-Nawas B, Nkenke E, Piesold JU, Pradel W, Rasse M, Rachwalski M, Reich RH, Rothamel D, Rustemeyer J, Scheer M, Schliephake H, Schmelzeisen R, Schramm A, Schupp W, Spitzer WJ, Stocker E, Stoll C, Terheyden H, Voigt A, Wagner W, Weingart D, Werkmeister R, Wiltfang J, Ziegler CM, Zoller JE (2018) Current concepts in cleft care: a multicenter analysis. J Craniomaxillofac Surg 46(4):705–708
Lexer E (1908) Die Verwendng der freien Knochenplastik nebst Versuchen über Gelenkversteifung und Gelenktransplantation. Langenbecks Arch Klin Chir Ver Dtsch Z Chir 86:939–954
von Eiselberg FW (1901) Zur Technik der Uranoplastik. Arch Klin Chir 61:509
Drachter R (1914) Die Gaumenspalte und deren operative Behandlung. Dtsch Z Chir 131:1–89
Veau V (1931) Division palatine. Masson et Cie, Paris
Veau V (1938) Bec-de-lièvre, formes cliniques – chirurgie. Masson et Cie, Paris
Wassmund M (1955) Reconstructive facial surgery. Dtsch Med J 6(1-2):24–30
Axhausen G (1952) Plastic surgery of cleft palate; relation to chewing function. Chirurg 23(9):403–405
Schmid E (1954) Constructive alveolar crest gnathoplasty. Osterr Z Stomatol 51(11):582–583
Schmid E (1960) Osteoplasty in harelip and cleft palate. Langenbecks Arch Klin Chir Ver Dtsch Z Chir 295:868–876
Schmid E, Widmaier W (1962) The use of autoplastic cartilage in reconstructive surgery of the face. Langenbecks Arch Klin Chir Ver Dtsch Z Chir 302:53–59
Schmid E, Widmaier W (1963) Simultaneous bone grafts with closure of the harelip. Ann Chir Plast 8:23–27
Schrudde J, Stellmach R (1958) Primary osteoplasty of defects of the inferior maxillary arch in cleft palate and harelip in infants; preliminary report. Zentralbl Chir 83(15):849–859
Stellmach R (1959) Primary bone plastic surgery in lip-maxilla cleft palate in infants with special reference to transplant covering. Langenbecks Arch Klin Chir Ver Dtsch Z Chir 292:865–869
Mc Neil CK (1956) Congenital oral deformaties. Br Dent J 101:191–198
Stellmach R (1955) The dentist’s task in caring for patients with cleft palates and harelips. Zahnarztl Rundsch 64(13):357–361
Schrudde J, Stellmach R (1959) Primäre Osteoplastik und Kieferbogenformung bei Lippen‑, Kiefer‑, Gaumenspalten. Fortschr Kiefer Gesichtschir 5:247–265
Johanson B, Ohlsson A (1960) Osteoplasty in the late treatment of harelip and cleft palate. Langenbecks Arch Klin Chir Ver Dtsch Z Chir 295:876–880
Johanson B, Ohlsson A (1961) Bone grafting and dental orthopaedics in primary and secondary cases of cleft lip and palate. Acta Chir Scand 122:112–124
Rehrmann A (1964) Congenital Deformities. 3. Bone Grafting in Cleft Palate Repair. Mod Trends Plast Surg 16:50–67
Brauer RO, Cronin TD, Reaves EL (1962) Early maxillary orthopedics, orthodontia and alveolar bone grafting in complete clefts of the palate. Plast Reconstr Surg Transplant Bull 29:625–641
Brauer RO, Cronin TD (1964) Maxillary orthopedics and anterior palate repair with Bone grafting. Cleft Palate J 16:31–42
Schuchardt K, Pfeifer G (1960) Experiences with primary bone transplantations in harelip and cleft palate. Langenbecks Arch Klin Chir Ver Dtsch Z Chir 295:881–884
Schuchardt K (1962) The current status of plastic surgery of the lips and palate. Arch Ohren Nasen Kehlkopfheilkd 180:517–537
Schuchardt K, Pfeifer G (1961) Documentation of patients with harelip and cleft palate. Langenbecks Arch Klin Chir Ver Dtsch Z Chir 298:679–685
Schuchardt K, Pfeifer G (1962) Primary and secondary operations for cleft palate. J Int Coll Surg 38:237–239
Hollmann K (1962) Osteoplasty in cheilognathouranoschisis. Klin Med Osterr Z Wiss Prakt Med 17:604–608
Schilli W (1969) The indications for and technique of secondary osteoplasty of cleft jaw. Panminerva Med 11(1):68–70
Nylen B, Korlof B, Arnander C, Leanderson R, Barr B, Nordin KE (1974) Primary, early bone grafting in complete grafts of the lip and palate. A follow-up study of 53 cases. Scand J Plast Reconstr Surg 8(1-2):79–87
Obwegeser H, Perko M (1968) Reconstruction of the bone defect in patients with cleft lip and cleft palate. Dtsch Zahn Mund Kieferheilkd Zentralbl Gesamte 50(5):203–210
Schwenzer N (1993) Bone repair in labia-maxillo-palatal defects. Laser in oro-maxillo-facial surgery. Proceedings of the 42nd Congress of the German Association for Oro-Maxillo-Facial Surgery. Fortschr Kiefer Gesichtschir 38:1–158 (Vorwort)
Ritter R (1959) Beurteilung des Zwischenkiefers bei Spaltkindern von seiten des Kieferchirurgen, des Orthopäden und des Prothetikers. Fortschr Kiefer Gesichtschir 5:242–246
Hollmann K, Tomasoni S (1965) Bone grafting in cheilo-gnatho-palatine clefts. Osp Ital Chir 13(1):21–28
Hollmann K, Tomasoni S (1965) Osteoplasty and Orthodontic Treatment in Cheilognathopalatoschisis. Arcisp S Anna Ferrara 18:157–171
Robertson NR (1983) Facial form of patients with cleft lip and palate. The long-term influence of presurgical oral orthopaedics. Br Dent J 155(2):59–61
Robertson NR, Jolleys A (1983) An 11-year follow-up of the effects of early bone grafting in infants born with complete clefts of the lip and palate. Br J Plast Surg 36(4):438–443
Herfert O (1954) Experimental contribution to the problem of injury to maxillary growth by premature cleft palate surgery. Dtsch Zahn Mund Kieferheilkd Zentralbl Gesamte 20(9-10):369–381
Herfert O (1958) Zur Chirurgie der Lippen‑, Kiefer‑, Gaumenspalten. Fortschr Kiefer Gesichtschir 4:414–418
Gabka J, Tayfun R (1970) Histological studies of the soft tissue covering of the premaxilla in bilateral cleft lip and palate. Dtsch Zahn Mund Kieferheilkd Zentralbl Gesamte 55(5):106–111
Eckstein T, Muhling J, Reuther J, Michel C (1993) Comparative long-term studies of growth behavior after lip-maxillary closure with and without primary osteoplasty. Fortschr Kiefer Gesichtschir 38:56–57
Koberg W, Koblin I (1973) Speech development and maxillary growth in relation to technique and timing of palatoplasty. J Maxillofac Surg 1(1):44–50
Rehrmann AH, Koberg WR, Koch H (1970) Long-term postoperative results of primary and secondary bone grafting in complete clefts of lip and palate. Cleft Palate J 7:206–221
Holtgrave EA (1986) Primary osteoplasty and a trial to determine its value from the orthodontic viewpoint. Fortschr Kieferorthop 47(5):412–420
Holtgrave EA, Subotic V, Kruger E, Drescher D, Lucke M (1989) Stabilization of maxillary segments and dental arch after puberty, in cleft lip and palate cases. J Craniomaxillofac Surg 17(Suppl 1):45–48
Keese E, Schmelzle R (1995) New findings concerning early bone grafting procedures in patients with cleft lip and palate. J Craniomaxillofac Surg 23(5):296–301
Feifel H, Schwenzer N (1991) Long-term results of primary osteoplasty in CLP patients. A cephalometric analysis. Dtsch Z Mund Kiefer Gesichtschir 15(5):376–381
Kruger E, Krumholz K, Niederhagen B, Drescher D (1993) Long-term results of unilateral lip-maxillary-palatal clefts with primary osteoplasty. Fortschr Kiefer Gesichtschir 38:53–55
Rosenstein SW, Monroe CW, Kernahan DA, Jacobson BN, Griffith BH, Bauer BS (1982) The case of early bone grafting in cleft lip and cleft palate. Plast Reconstr Surg 70(3):297–309
Steinhäuser EW, Gottsauer A (1991) Long term results following primary osteoplasty in cleft lip and palate patients. In: Pfeifer G (Hrsg) Craniofacial abnormalities and clefts of the lipe, alveolus and palate. Thieme, Stuttgart, S 374–378
Bergland O, Semb G, Abyholm FE (1986) Elimination of the residual alveolar cleft by secondary bone grafting and subsequent orthodontic treatment. Cleft Palate J 23(3):175–205
Pfeifer G (1993) Development, morphology and growth of alveolar stumps in maxillary clefts as the basic principles of osteoplasty. Fortschr Kiefer Gesichtschir 38:15–26
Boyne PJ, Sands NR (1972) Secondary bone grafting of residual alveolar and palatal clefts. J Oral Surg 30(2):87–92
Dixon DA, Edwards JR, Newton I (1976) Orthodontically induced eruption of the permanent canine combined with alveolar cleft osteoplasty: a new procedure illustrated by a case with stereophotogrammetric reconstructions. J Maxillofac Surg 4(1):61–65
Ahn G, Lee JS, Yun WS, Shim JH, Lee UL (2018) Cleft alveolus reconstruction using a three-dimensional printed Bioresorbable scaffold with human Bone marrow cells. J Craniofac Surg. https://doi.org/10.1097/SCS.0000000000004747
Freihofer HP, Borstlap WA, Kuijpers-Jagtman AM, Voorsmit RA, van Damme PA, Heidbuchel KL, Borstlap-Engels VM (1993) Timing and transplant materials for closure of alveolar clefts. A clinical comparison of 296 cases. J Craniomaxillofac Surg 21(4):143–148
Horswell BB, Henderson JM (2003) Secondary osteoplasty of the alveolar cleft defect. J Oral Maxillofac Surg 61(9):1082–1090
Le BT, Woo I (2009) Alveolar cleft repair in adults using guided bone regeneration with mineralized allograft for dental implant site development: a report of 2 cases. J Oral Maxillofac Surg 67(8):1716–1722
Ochs MW (1996) Alveolar cleft bone grafting (Part II): secondary bone grafting. J Oral Maxillofac Surg 54(1):83–88
Zouhary KJ (2010) Bone graft harvesting from distant sites: concepts and techniques. Oral Maxillofac Surg Clin North Am 22(3):301–316
Kamal M, Gremse F, Rosenhain S, Bartella AK, Holzle F, Kessler P, Lethaus B (2018) Comparison of bone grafts from various donor sites in human bone specimens. J Craniofac Surg. https://doi.org/10.1097/SCS.0000000000004586
Liang F, Leland H, Jedrzejewski B, Auslander A, Maniskas S, Swanson J, Urata M, Hammoudeh J, Magee W 3rd (2018) Alternatives to Autologous Bone graft in alveolar cleft reconstruction: the state of alveolar tissue engineering. J Craniofac Surg 29(3):584–593
Al Harbi H, Al Yamani A (2012) Long-term follow-up of tibial bone graft for correction of alveolar cleft. Ann Maxillofac Surg 2(2):146–152
Fukuta K, Kurita K, Goto M, Nakayama A, Maeda M, Watanabe H (2017) Invasiveness of tibial bone graft harvesting for secondary alveolar bone grafting: Can harvesting be performed at the age of less than 10 years without complications? J Oral Maxillofac Surg 75(12):2628–2637
Walker TW, Modayil PC, Cascarini L, Williams L, Duncan SM, Ward-Booth P (2009) Retrospective review of donor site complications after harvest of cancellous bone from the anteriomedial tibia. Br J Oral Maxillofac Surg 47(1):20–22
Eichhorn W, Blessmann M, Pohlenz P, Blake FA, Gehrke G, Schmelzle R, Heiland M (2009) Primary osteoplasty using calvarian bone in patients with cleft lip, alveolus and palate. J Craniomaxillofac Surg 37(8):429–433
Hudak KA, Hettinger P, Denny AD (2014) Cranial bone grafting for alveolar clefts: a 25-year review of outcomes. Plast Reconstr Surg 133(5):662e–668e
Cohen M, Figueroa AA, Haviv Y, Schafer ME, Aduss H (1991) Iliac versus cranial bone for secondary grafting of residual alveolar clefts. Plast Reconstr Surg 87(3):423–427 (discussion 428)
Tessier P, Tulasne JF (1984) Secondary repair of cleft lip deformity. Clin Plast Surg 11(4):747–760
Wolfe SA, Berkowitz S (1983) The use of cranial bone grafts in the closure of alveolar and anterior palatal clefts. Plast Reconstr Surg 72(5):659–671
Strong EB, Moulthrop T (2000) Calvarial bone graft harvest: a new technique. Otolaryngol Head Neck Surg 123(5):547–552
Baqain ZH, Anabtawi M, Karaky AA, Malkawi Z (2009) Morbidity from anterior iliac crest bone harvesting for secondary alveolar bone grafting: an outcome assessment study. J Oral Maxillofac Surg 67(3):570–575
Chang BL, Wilson AJ, Chin BC, Friedman C, Jackson OA (2017) Influence of standardized orientation on patient perception of perioperative care following alveolar cleft repair: a survey based study of patients treated in a large academic medical center. Cleft Palate Craniofac J 54(3):287–294
Weissler EH, Paine KM, Ahmed MK, Taub PJ (2016) Alveolar Bone grafting and cleft lip and palate: a review. Plast Reconstr Surg 138(6):1287–1295
Eppley BL (2005) Donor site morbidity of rib graft harvesting in primary alveolar cleft bone grafting. J Craniofac Surg 16(2):335–338
van Aalst JA, Eppley BL, Hathaway RR, Sadove AM (2005) Surgical technique for primary alveolar bone grafting. J Craniofac Surg 16(4):706–711
Eppley BL, Sadove AM (2000) Management of alveolar cleft bone grafting—state of the art. Cleft Palate Craniofac J 37(3):229–233
Park YW, Lee JH (2016) Use of mandibular chin bone for alveolar bone grafting in cleft patients. Maxillofac Plast Reconstr Surg 38(1):45
Borstlap WA, Heidbuchel KL, Freihofer HP, Kuijpers-Jagtman AM (1990) Early secondary bone grafting of alveolar cleft defects. A comparison between chin and rib grafts. J Craniomaxillofac Surg 18(5):201–205
Shirzadeh A, Rahpeyma A, Khajehahmadi S (2018) A prospective study of chin bone graft harvesting for unilateral maxillary alveolar cleft during mixed dentition. J Oral Maxillofac Surg 76(1):180–188
Amin K, Khor WS, Rosich-Medina A, Beale V (2017) Alveolar bone grafting: donor site review of 100 consecutive cases in cleft lip and palate. Cleft Palate Craniofac J 54(2):137–141
Swan MC, Goodacre TE (2006) Morbidity at the iliac crest donor site following bone grafting of the cleft alveolus. Br J Oral Maxillofac Surg 44(2):129–133
Besly W, Ward Booth P (1999) Technique for harvesting tibial cancellous bone modified for use in children. Br J Oral Maxillofac Surg 37(2):129–133
Alberius P, Dahlin C, Linde A (1992) Role of osteopromotion in experimental bone grafting to the skull: a study in adult rats using a membrane technique. J Oral Maxillofac Surg 50(8):829–834
Koole R, Bosker H, van der Dussen FN (1989) Late secondary autogenous bone grafting in cleft patients comparing mandibular (ectomesenchymal) and iliac crest (mesenchymal) grafts. J Craniomaxillofac Surg 17(Suppl 1):28–30
Wilkes GH, Kernahan DA, Christenson M (1985) The long-term survival of onlay bone grafts—a comparative study in mature and immature animals. Ann Plast Surg 15(5):374–378
Kline RM Jr., Wolfe SA (1995) Complications associated with the harvesting of cranial bone grafts. Plast Reconstr Surg 95(1):5–13 (discussion 14–20)
Boyde A, Hendel P, Hendel R, Maconnachie E, Jones SJ (1990) Human cranial bone structure and the healing of cranial bone grafts: a study using backscattered electron imaging and confocal microscopy. Anat Embryol (berl) 181(3):235–251
LaRossa D, Buchman S, Rothkopf DM, Mayro R, Randall P (1995) A comparison of iliac and cranial bone in secondary grafting of alveolar clefts. Plast Reconstr Surg 96(4):789–797 (discussion 798–789)
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Gröbe, A., Gehrke, G. Die primäre Kalottenosteoplastik bei Lippen-Kiefer-Gaumen-Spalten. MKG-Chirurg 11, 234–242 (2018). https://doi.org/10.1007/s12285-018-0175-0
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DOI: https://doi.org/10.1007/s12285-018-0175-0